FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043970365> ?p ?o ?g. }

• W2043970365 endingPage "814" @default.
• W2043970365 startingPage "805" @default.
• W2043970365 abstract "Background: The P4 strain of the corn smut fungus, Ustilago maydis, secretes a fungal toxin, KP4, encoded by a fungal virus (UMV4) that persistently infects its cells. UMV4, unlike most other (non-fungal) viruses, does not spread to uninfected cells by release into the extracellular milieu during its normal life cycle and is thus dependent upon host survival for replication. In symbiosis with the host fungus, UMV4 encodes KP4 to kill other competitive strains of U. maydis, thereby promoting both host and virus survival. KP4 belongs to a family of fungal toxins and determining its structure should lead to a better understanding of the function and evolutionary origins of these toxins. Elucidation of the mechanism of toxin action could lead to new anti-fungal agents against human pathogens.Results We have determined the atomic structure of KP4 to 1.9 å resolution. KP4 belongs to the α/β-sandwich family, and has a unique topology comprising a five-stranded antiparallel β-sheet with two antiparallel α-helices lying at ∼45° to these strands. The structure has two left-handed βαβ cross-overs and a basic protuberance extending from the β-sheet. In vivo experiments demonstrated abrogation of toxin killing by Ca2+ and, to a lesser extent, Mg2+. These results led to experiments demonstrating that the toxin specifically inhibits voltage-gated Ca2+ channels in mammalian cells.Conclusion Similarities, although somewhat limited, between KP4 and scorpion toxins led us to investigate the possibility that the toxic effects of KP4 may be mediated by inhibition of cation channels. Our results suggest that certain properties of fungal Ca2+ channels are homologous to those in mammalian cells. KP4 may, therefore, be a new tool for studying mammalian Ca2+ channels and current mammalian Ca2+ channel inhibitors may be useful lead compounds for new anti-fungal agents." @default.
• W2043970365 created "2016-06-24" @default.
• W2043970365 creator A5002705400 @default.
• W2043970365 creator A5006319739 @default.
• W2043970365 creator A5036814884 @default.
• W2043970365 creator A5038023336 @default.
• W2043970365 creator A5062318557 @default.
• W2043970365 creator A5081728024 @default.
• W2043970365 date "1995-08-01" @default.
• W2043970365 modified "2023-10-16" @default.
• W2043970365 title "Structure and function of a virally encoded fungal toxin from Ustilago maydis: a fungal and mammalian Ca2+ channel inhibitor" @default.
• W2043970365 cites W1535002880 @default.
• W2043970365 cites W1561361130 @default.
• W2043970365 cites W1583884783 @default.
• W2043970365 cites W1927083604 @default.
• W2043970365 cites W1963596507 @default.
• W2043970365 cites W1965915558 @default.
• W2043970365 cites W1975336901 @default.
• W2043970365 cites W1986191025 @default.
• W2043970365 cites W1987201985 @default.
• W2043970365 cites W1993404146 @default.
• W2043970365 cites W2001641653 @default.
• W2043970365 cites W2005254140 @default.
• W2043970365 cites W2011622099 @default.
• W2043970365 cites W2013083986 @default.
• W2043970365 cites W2019652308 @default.
• W2043970365 cites W2029501303 @default.
• W2043970365 cites W2031505659 @default.
• W2043970365 cites W2038677653 @default.
• W2043970365 cites W2044405979 @default.
• W2043970365 cites W2044825477 @default.
• W2043970365 cites W2046071134 @default.
• W2043970365 cites W2050665726 @default.
• W2043970365 cites W2053902929 @default.
• W2043970365 cites W2062457450 @default.
• W2043970365 cites W2063316371 @default.
• W2043970365 cites W2065691071 @default.
• W2043970365 cites W2066878702 @default.
• W2043970365 cites W2069106845 @default.
• W2043970365 cites W2073224981 @default.
• W2043970365 cites W2078507839 @default.
• W2043970365 cites W2083869948 @default.
• W2043970365 cites W2095517820 @default.
• W2043970365 cites W2102558845 @default.
• W2043970365 cites W2135192859 @default.
• W2043970365 cites W2136455040 @default.
• W2043970365 cites W2143297099 @default.
• W2043970365 cites W2166020427 @default.
• W2043970365 cites W2170208303 @default.
• W2043970365 cites W2170646800 @default.
• W2043970365 cites W2173767510 @default.
• W2043970365 cites W2184759320 @default.
• W2043970365 cites W2317171109 @default.
• W2043970365 cites W2763180113 @default.
• W2043970365 cites W4248628414 @default.
• W2043970365 cites W4251783343 @default.
• W2043970365 cites W4299785644 @default.
• W2043970365 cites W75255720 @default.
• W2043970365 doi "https://doi.org/10.1016/s0969-2126(01)00215-5" @default.
• W2043970365 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7582897" @default.
• W2043970365 hasPublicationYear "1995" @default.
• W2043970365 type Work @default.
• W2043970365 sameAs 2043970365 @default.
• W2043970365 citedByCount "52" @default.
• W2043970365 countsByYear W20439703652012 @default.
• W2043970365 countsByYear W20439703652013 @default.
• W2043970365 countsByYear W20439703652014 @default.
• W2043970365 countsByYear W20439703652017 @default.
• W2043970365 countsByYear W20439703652018 @default.
• W2043970365 countsByYear W20439703652019 @default.
• W2043970365 countsByYear W20439703652021 @default.
• W2043970365 countsByYear W20439703652022 @default.
• W2043970365 countsByYear W20439703652023 @default.
• W2043970365 crossrefType "journal-article" @default.
• W2043970365 hasAuthorship W2043970365A5002705400 @default.
• W2043970365 hasAuthorship W2043970365A5006319739 @default.
• W2043970365 hasAuthorship W2043970365A5036814884 @default.
• W2043970365 hasAuthorship W2043970365A5038023336 @default.
• W2043970365 hasAuthorship W2043970365A5062318557 @default.
• W2043970365 hasAuthorship W2043970365A5081728024 @default.
• W2043970365 hasBestOaLocation W20439703651 @default.
• W2043970365 hasConcept C104317684 @default.
• W2043970365 hasConcept C115260700 @default.
• W2043970365 hasConcept C121332964 @default.
• W2043970365 hasConcept C142089489 @default.
• W2043970365 hasConcept C2777367657 @default.
• W2043970365 hasConcept C2779678110 @default.
• W2043970365 hasConcept C2781222273 @default.
• W2043970365 hasConcept C54355233 @default.
• W2043970365 hasConcept C59822182 @default.
• W2043970365 hasConcept C62520636 @default.
• W2043970365 hasConcept C86803240 @default.
• W2043970365 hasConcept C89423630 @default.
• W2043970365 hasConceptScore W2043970365C104317684 @default.
• W2043970365 hasConceptScore W2043970365C115260700 @default.
• W2043970365 hasConceptScore W2043970365C121332964 @default.
• W2043970365 hasConceptScore W2043970365C142089489 @default.
• W2043970365 hasConceptScore W2043970365C2777367657 @default.

• next