Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043972904> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2043972904 endingPage "61" @default.
- W2043972904 startingPage "55" @default.
- W2043972904 abstract "Studies have shown that trans fatty acids may play a role in the development of chronic diseases such as heart disease and cancer. The objective of the present project was to examine the effect of supplementation with 18:1 isomers, both positional and geometrical, as compared to 18:0 on the growth, membrane fatty acid composition and the phosphoinositide cycle of HT-29 human colon cancer cells. Cells were supplemented with 30 μM stearic acid (18:0), elaidic acid (18:1, n9, trans), oleic acid (18:1, n9, cis), vaccenic acid (18:1, n7, as) or trans-vaccenic acid (18:1, n7, trans) as sodium salts complexed to fatty acid-free bovine serum. Cells were grown in these media for 9 days. Cell growth was examined by counting the number of cells and expressed as percentage of control (18:0 supplemented cells). The phosphoinositide (PI) cycle was examined by measuring the inositol phosphate (IP) released from phosphoinositides in the absence (basal) or presence of stimuli (0.1 mM carbachol, 0.1 mM A23187 or 20 mM NaF). The results obtained indicated that cis and trans n7 fatty acids inhibited the growth of HT-29 cells by 11% and 23%, respectively, as compared to 18:0 supplementation. 18:1, n9 had no effect on tumor growth. Supplementation with all forms of 18:1 resulted in an increase in IP and IP2 production as compared to 18:0 supplemented cells without influencing IP3. The presence of the double bond at the 9 position in the supplemented fatty acid increases total IP production by 59% and in the cis form by 37% above the control. The breakdown of phosphoinositides in the absence and presence of several stimuli supports the observed finding on IP. Trans fatty acid supplementation resulted in lower hydrolysis of PI as compared to cis fatty acids. It is concluded that the observed inhibition of tumor growth by the vaccenic acids may be mediated by their effect(s) on the PI cycle which may be associated with their incorporation into membrane lipids." @default.
- W2043972904 created "2016-06-24" @default.
- W2043972904 creator A5016850242 @default.
- W2043972904 creator A5019057290 @default.
- W2043972904 creator A5028712610 @default.
- W2043972904 creator A5037617915 @default.
- W2043972904 date "1995-05-01" @default.
- W2043972904 modified "2023-09-27" @default.
- W2043972904 title "18:1 n7 fatty acids inhibit growth and decrease inositol phosphate release in HT-29 cells compared to n9 fatty acids" @default.
- W2043972904 cites W1966743401 @default.
- W2043972904 cites W1988870004 @default.
- W2043972904 cites W2000792791 @default.
- W2043972904 cites W2026293587 @default.
- W2043972904 cites W2029489272 @default.
- W2043972904 cites W2053751245 @default.
- W2043972904 cites W2081610379 @default.
- W2043972904 cites W2174430306 @default.
- W2043972904 cites W2405348828 @default.
- W2043972904 cites W2419344695 @default.
- W2043972904 cites W2419673762 @default.
- W2043972904 doi "https://doi.org/10.1016/0304-3835(95)03725-c" @default.
- W2043972904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7750095" @default.
- W2043972904 hasPublicationYear "1995" @default.
- W2043972904 type Work @default.
- W2043972904 sameAs 2043972904 @default.
- W2043972904 citedByCount "35" @default.
- W2043972904 countsByYear W20439729042012 @default.
- W2043972904 countsByYear W20439729042013 @default.
- W2043972904 countsByYear W20439729042014 @default.
- W2043972904 countsByYear W20439729042015 @default.
- W2043972904 countsByYear W20439729042016 @default.
- W2043972904 countsByYear W20439729042017 @default.
- W2043972904 countsByYear W20439729042018 @default.
- W2043972904 countsByYear W20439729042020 @default.
- W2043972904 countsByYear W20439729042022 @default.
- W2043972904 countsByYear W20439729042023 @default.
- W2043972904 crossrefType "journal-article" @default.
- W2043972904 hasAuthorship W2043972904A5016850242 @default.
- W2043972904 hasAuthorship W2043972904A5019057290 @default.
- W2043972904 hasAuthorship W2043972904A5028712610 @default.
- W2043972904 hasAuthorship W2043972904A5037617915 @default.
- W2043972904 hasConcept C170493617 @default.
- W2043972904 hasConcept C178790620 @default.
- W2043972904 hasConcept C185592680 @default.
- W2043972904 hasConcept C2777427919 @default.
- W2043972904 hasConcept C2777921831 @default.
- W2043972904 hasConcept C2778618036 @default.
- W2043972904 hasConcept C2778738395 @default.
- W2043972904 hasConcept C2779516699 @default.
- W2043972904 hasConcept C2779780233 @default.
- W2043972904 hasConcept C2780809830 @default.
- W2043972904 hasConcept C2781403372 @default.
- W2043972904 hasConcept C543025807 @default.
- W2043972904 hasConcept C55493867 @default.
- W2043972904 hasConcept C62112901 @default.
- W2043972904 hasConcept C86803240 @default.
- W2043972904 hasConceptScore W2043972904C170493617 @default.
- W2043972904 hasConceptScore W2043972904C178790620 @default.
- W2043972904 hasConceptScore W2043972904C185592680 @default.
- W2043972904 hasConceptScore W2043972904C2777427919 @default.
- W2043972904 hasConceptScore W2043972904C2777921831 @default.
- W2043972904 hasConceptScore W2043972904C2778618036 @default.
- W2043972904 hasConceptScore W2043972904C2778738395 @default.
- W2043972904 hasConceptScore W2043972904C2779516699 @default.
- W2043972904 hasConceptScore W2043972904C2779780233 @default.
- W2043972904 hasConceptScore W2043972904C2780809830 @default.
- W2043972904 hasConceptScore W2043972904C2781403372 @default.
- W2043972904 hasConceptScore W2043972904C543025807 @default.
- W2043972904 hasConceptScore W2043972904C55493867 @default.
- W2043972904 hasConceptScore W2043972904C62112901 @default.
- W2043972904 hasConceptScore W2043972904C86803240 @default.
- W2043972904 hasIssue "1" @default.
- W2043972904 hasLocation W20439729041 @default.
- W2043972904 hasLocation W20439729042 @default.
- W2043972904 hasOpenAccess W2043972904 @default.
- W2043972904 hasPrimaryLocation W20439729041 @default.
- W2043972904 hasRelatedWork W1608503145 @default.
- W2043972904 hasRelatedWork W2023286643 @default.
- W2043972904 hasRelatedWork W2043972904 @default.
- W2043972904 hasRelatedWork W2189546134 @default.
- W2043972904 hasRelatedWork W2221775138 @default.
- W2043972904 hasRelatedWork W2579976130 @default.
- W2043972904 hasRelatedWork W258981257 @default.
- W2043972904 hasRelatedWork W2625744389 @default.
- W2043972904 hasRelatedWork W3125678446 @default.
- W2043972904 hasRelatedWork W560398229 @default.
- W2043972904 hasVolume "91" @default.
- W2043972904 isParatext "false" @default.
- W2043972904 isRetracted "false" @default.
- W2043972904 magId "2043972904" @default.
- W2043972904 workType "article" @default.