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- W2043974270 abstract "Sir, Extramedullary cutaneous plasmacytoma is an uncommon disease. Primary cutaneous plasmacytoma is extremely rare, with only about 30 cases documented in the literature.1 Secondary cutaneous plasmacytoma accounts for only 5–10% of secondary plasmacytomas.2 It usually appears at an advanced stage of myeloma, accompanying the infiltration of other organs by plasma cells.3 Rongioletti and Rebora,4 in an update of their classification of cutaneous mucinoses, described, within distinctive (primary) mucinoses, a group of mucinoses associated with plasma cell dyscrasia, including lichen myxoedematosus (papular mucinosis, scleromyxoedema), scleroedema, diffuse myxoedema, follicular mucinosis and reticular erythematous mucinosis. We report a case of simultaneous presentation of cutaneous mucinosis and plasma cell dyscrasia where a single infiltrated oedematous facial lesion with histopathological features of cutaneous mucinosis led to the diagnosis of secondary extramedullary plasmacytoma. A 74‐year‐old man, with a history of penicillin allergy, ischaemic cardiopathy, arterial hypertension, prostatism and chronic obstructive pulmonary disease, presented with a nonpainful, erythematous cutaneous lesion on the left zygomatic area. Examination revealed a 7‐cm nodular infiltrated lesion, with an erythematous surface and an oedematous appearance (Fig. 1A). Skin biopsy showed, subjacent to a normal epidermis, an expanded papillary dermis with sparing of collagen bundles, accompanied by a perivascular lymphocytic infiltrate. An Alcian blue stain revealed the presence of abundant mucin in the papillary and reticular dermis, mainly around follicular units (Fig. 1B). Direct immunofluorescence was negative. Routine laboratory studies showed haemoglobin 12 g dL−1, haematocrit 36, white cell count 7·78 × 109 L−1 with normal differential, and platelets 330 × 109 L−1. Blood biochemistry and coagulation were normal. Chest X‐ray, radiology of the paranasal sinus and orthopanthomography were normal." @default.
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- W2043974270 date "2004-02-01" @default.
- W2043974270 modified "2023-10-18" @default.
- W2043974270 title "Localized cutaneous mucinosis as a presentation of secondary extramedullary cutaneous plasmacytoma" @default.
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- W2043974270 doi "https://doi.org/10.1111/j.1365-2133.2004.05730.x" @default.
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