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- W2043974718 abstract "The aim of the present study was to assess whether calcitonin gene-related peptide (CGRP) modulates exocytotic norepinephrine release in ischemic myocardium. In isolated rat hearts subjected to 30 min of low flow ischemia, CGRP release increased 2.8-fold whereas stimulation-induced norepinephrine release decreased 4.1-fold. Pretreatment of rats with capsaicin almost completely depleted cardiac CGRP stores; however, suppression of norepinephrine release by 30 min of low flow ischemia was not affected. At normal flow, exogenous CGRP (5 micromol l-1) had no effect on norepinephrine release. These findings suggest that CGRP release from sensory neurons does not interact with the cardiac sympathetic system during myocardial ischemia." @default.
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- W2043974718 date "2005-02-01" @default.
- W2043974718 modified "2023-10-16" @default.
- W2043974718 title "Calcitonin gene-related peptide does not interact with sympathetic activity in myocardial ischemia" @default.
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- W2043974718 doi "https://doi.org/10.1016/j.regpep.2004.08.002" @default.
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