FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043977379> ?p ?o ?g. }

• W2043977379 endingPage "2657" @default.
• W2043977379 startingPage "2650" @default.
• W2043977379 abstract "A novel class of non-viral gene vectors consisting of low molecular weight poly(ethylene imine) (PEI) (molecular weight 800 Da) grafted onto degradable linear poly(ethylene glycol) (PEG) analogs was synthesized. First, a Michael addition reaction between poly(ethylene glycol) diacrylates (PEGDA) (molecular weight 258 Da) and d,l-dithiothreitol (DTT) was carried out to generate a linear polymer (PEG–DTT) having a terminal thiol, methacrylate and pendant hydroxyl functional groups. Five PEG–DTT analogs were synthesized by varying the molar ratio of diacrylates to thiols from 1.2:1 to 1:1.2. Then PEI (800 Da) was grafted onto the main chain of the PEG–DTTs using 1,1′-carbonyldiimidazole as the linker. The above reaction gave rise to a new class of non-viral gene vectors, (PEG–DTT)–g-PEI copolymers, which can effectively complex DNA to form nanoparticles. The molecular weights and structures of the copolymers were characterized by gel permeation chromatography, 1H nuclear magnetic resonance and Fourier transform infrared spectroscopy. The size of the nanoparticles was <200 nm and the surface charge of the nanoparticles, expressed as the zeta potential, was between +20 and +40 mV. Cytotoxicity assays showed that the copolymers exhibited much lower cytotoxicities than high molecular weight PEI (25 kDa). Transfection was performed in cultured HeLa, HepG2, MCF-7 and COS-7 cells. The copolymers showed higher transfection efficiencies than PEI (25 kDa) tested in four cell lines. The presence of serum (up to 30%) had no inhibitory effect on the transfection efficiency. These results indicate that this new class of non-viral gene vectors may be a promising gene carrier that is worth further investigation." @default.
• W2043977379 created "2016-06-24" @default.
• W2043977379 creator A5010656036 @default.
• W2043977379 creator A5024268530 @default.
• W2043977379 creator A5028875731 @default.
• W2043977379 creator A5044243840 @default.
• W2043977379 creator A5044620494 @default.
• W2043977379 creator A5052754475 @default.
• W2043977379 creator A5058855220 @default.
• W2043977379 date "2010-07-01" @default.
• W2043977379 modified "2023-10-13" @default.
• W2043977379 title "Poly(ethylene glycol) analogs grafted with low molecular weight poly(ethylene imine) as non-viral gene vectors" @default.
• W2043977379 cites W1560355462 @default.
• W2043977379 cites W1970995707 @default.
• W2043977379 cites W1973458116 @default.
• W2043977379 cites W1976532926 @default.
• W2043977379 cites W1977922381 @default.
• W2043977379 cites W1988011402 @default.
• W2043977379 cites W1988246626 @default.
• W2043977379 cites W1996359986 @default.
• W2043977379 cites W2002903271 @default.
• W2043977379 cites W2006604904 @default.
• W2043977379 cites W2012926766 @default.
• W2043977379 cites W2024939468 @default.
• W2043977379 cites W2031749799 @default.
• W2043977379 cites W2033283232 @default.
• W2043977379 cites W2037595752 @default.
• W2043977379 cites W2043069157 @default.
• W2043977379 cites W2047609968 @default.
• W2043977379 cites W2048928172 @default.
• W2043977379 cites W2052478070 @default.
• W2043977379 cites W2057402201 @default.
• W2043977379 cites W2059839011 @default.
• W2043977379 cites W2074870430 @default.
• W2043977379 cites W2077391475 @default.
• W2043977379 cites W2080071319 @default.
• W2043977379 cites W2086138918 @default.
• W2043977379 cites W2086731246 @default.
• W2043977379 cites W2086848733 @default.
• W2043977379 cites W2093971940 @default.
• W2043977379 cites W2094101506 @default.
• W2043977379 cites W2151067374 @default.
• W2043977379 cites W2170553025 @default.
• W2043977379 cites W304669699 @default.
• W2043977379 doi "https://doi.org/10.1016/j.actbio.2010.01.022" @default.
• W2043977379 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20114089" @default.
• W2043977379 hasPublicationYear "2010" @default.
• W2043977379 type Work @default.
• W2043977379 sameAs 2043977379 @default.
• W2043977379 citedByCount "32" @default.
• W2043977379 countsByYear W20439773792012 @default.
• W2043977379 countsByYear W20439773792013 @default.
• W2043977379 countsByYear W20439773792014 @default.
• W2043977379 countsByYear W20439773792015 @default.
• W2043977379 countsByYear W20439773792016 @default.
• W2043977379 countsByYear W20439773792017 @default.
• W2043977379 countsByYear W20439773792018 @default.
• W2043977379 countsByYear W20439773792019 @default.
• W2043977379 countsByYear W20439773792020 @default.
• W2043977379 countsByYear W20439773792021 @default.
• W2043977379 countsByYear W20439773792023 @default.
• W2043977379 crossrefType "journal-article" @default.
• W2043977379 hasAuthorship W2043977379A5010656036 @default.
• W2043977379 hasAuthorship W2043977379A5024268530 @default.
• W2043977379 hasAuthorship W2043977379A5028875731 @default.
• W2043977379 hasAuthorship W2043977379A5044243840 @default.
• W2043977379 hasAuthorship W2043977379A5044620494 @default.
• W2043977379 hasAuthorship W2043977379A5052754475 @default.
• W2043977379 hasAuthorship W2043977379A5058855220 @default.
• W2043977379 hasConcept C10138342 @default.
• W2043977379 hasConcept C104317684 @default.
• W2043977379 hasConcept C13965031 @default.
• W2043977379 hasConcept C155672457 @default.
• W2043977379 hasConcept C15920480 @default.
• W2043977379 hasConcept C162324750 @default.
• W2043977379 hasConcept C171250308 @default.
• W2043977379 hasConcept C178790620 @default.
• W2043977379 hasConcept C181199279 @default.
• W2043977379 hasConcept C185592680 @default.
• W2043977379 hasConcept C188027245 @default.
• W2043977379 hasConcept C192562407 @default.
• W2043977379 hasConcept C2777516009 @default.
• W2043977379 hasConcept C2777824588 @default.
• W2043977379 hasConcept C521977710 @default.
• W2043977379 hasConcept C54009773 @default.
• W2043977379 hasConcept C54400483 @default.
• W2043977379 hasConcept C55493867 @default.
• W2043977379 hasConcept C63179538 @default.
• W2043977379 hasConcept C86181022 @default.
• W2043977379 hasConceptScore W2043977379C10138342 @default.
• W2043977379 hasConceptScore W2043977379C104317684 @default.
• W2043977379 hasConceptScore W2043977379C13965031 @default.
• W2043977379 hasConceptScore W2043977379C155672457 @default.
• W2043977379 hasConceptScore W2043977379C15920480 @default.
• W2043977379 hasConceptScore W2043977379C162324750 @default.
• W2043977379 hasConceptScore W2043977379C171250308 @default.
• W2043977379 hasConceptScore W2043977379C178790620 @default.
• W2043977379 hasConceptScore W2043977379C181199279 @default.

• next