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• W2043978141 abstract "The patterns of longitudinal changes in systolic blood pressure (SBP), diastolic blood pressure (DBP) and body mass index (BMI = weightheight2) are explored on 3054 male subjects who remained alive and free of ischemie heart disease and/or stroke after 27 yr of follow-up in the Manitoba Follow-up Study. BMI tends to increase during adulthood, maintains in middle ages, and drops in old ages. With moderate acceleration, SBP continues to rise with age. DBP tends to rise with age until mid-fifties and then levels off. The correlations of age with BMI changes over time from significant positive at entry to significant negative by the end of the study period. The correlation of age with SBP changes from non-significant to highly significant positive; and with DBP, the correlation is significant but increases only in the first 10 yr, after which it fluctuates and decreases. These findings have implications on the relative importance of BMI, SBP andd DBP as coronary risk factors in younger and older men. Despite the high variability of blood pressure and the regression toward the mean phenomenon, BMI, SBP and DBP tend to retain their relative positions in their own distributions even after 25 yr. The correlation between the initial and later readings decreases with time but remains highly significant. The correlation between two readings five years apart is stronger in older men than in younger men. The future levels of blood pressure are predictable not only by its own attained levels, but also by age and BMI. Inclusion of all three of these factors improves the prediction. The overall distribution of the linear rate of change in BMI is bimodal, whereas that of SBP and DBP is unimodal. The differences in age does not account for these distributions, because similar unimodalities are also observed in men of the same single age. The variations in the rate of rise for men of the same single age indicate that factors other than age are responsible. Strong positive association between age and the mean linear rate of rise also indicate that the responsible factors are acting more effectively in older men. On the rate of rise, analytical results support the importance of age, not the attained level of blood pressure. The attained level of BMI, though strongly associated with the levels of blood pressure, is not related to the rate of change in blood pressure. The change of BMI, however, is strongly associated with those of blood pressure. In young men, the change of BMI is similarly associated with those of SBP and DBP; in older men, it is more related to that of DBP. As a mean of controlling high blood pressure, early prevention of weight gain is suggested. Although SBP and DBP are highly correlated and their correlation improves with time, evidence shows that they do not have the same pattern of change: SBP follows a fluctuating upward trend while DBP follows a quadratic trend. These observations confirm the findings from cross-sectional studies. By using orthogonal transformation, the parameters of an orthogonal polynomial fitted exactly to each individual are analyzed. This method of analysis gives similar results as obtained by using other methods and is shown to be simple, informative and effective in describing individual patterns of change over time, suggesting evidence of etiological interest and establishing relationships between trends of change." @default.
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• W2043978141 title "Blood pressure and body mass index patterns—A longitudinal study" @default.
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• W2043978141 doi "https://doi.org/10.1016/0021-9681(77)90078-9" @default.
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