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- W2043980069 abstract "Radioiodinated 5-(1-hydroxy-2-iodoethyl)-2′-deoxyuridine (1a) and 5-(1-methoxy-2-iodoethyl)-2′-deoxyuridine (2a) were prepared from the corresponding unlabelled nucleosides (1 and 2) by isotope exchange in a pivalic acid melt. Compound 1a was obtained in 71.3% to 26.3% radiochemical yield with a specific activity range of 77 to 2486 GBq/mmol, and 2a was prepared in 70.3% radiochemical yield at a specific activity of 100.6 GBq/mmol. Low temperatures and the mild reaction conditions encountered in the pivalic acid melt method, which reduce the extent of nucleoside decomposition, were essential for successful exchange radioiodination. Even under optimal conditions (70°C; 100 min), the order in which the reagents were mixed was critical to obtain high radiochemical yields and to minimize chemical decomposition of the nucleosides." @default.
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- W2043980069 date "1990-03-01" @default.
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- W2043980069 title "An efficient, high specific activity radioiodination of 5-(1-hydroxy/methoxy-2-iodoethyl)-2′-deoxyuridine by isotope exchange labelling in pivalic acid melt" @default.
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- W2043980069 doi "https://doi.org/10.1002/jlcr.2580280302" @default.
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