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• W2043988994 abstract "The accurate documentation of hair loss is important when monitoring disease progression and treatment efficacy. In clinical trials of minoxidil topical solution, hair count data obtained via macrophotography and image analysis from a 1-cm2 target area of the scalp provides an accurate, objective, and reproducible means of measuring hair loss and regrowth. However, this method requires technical expertise and specialized photographic equipment and is not practical for clinicians or for patients to use at home. We conducted a study of an adaptation of the 60-second timed hair count performed by Kligman in 1961. We enrolled a larger sample size of 40 healthy women between the ages of 20 and 60 years, 20 women between 20–40 years and 20 women between 41–60 years. Female volunteers were instructed to shampoo their hair on each of 3 consecutive days. Using a standard comb, they combed their hair forward for 60 seconds each day allowing the shed hairs to fall onto a towel or pillowcase. They recorded the number of shed hairs in a diary and completed a questionnaire. Baseline 60-second hair counts were reported in an earlier poster. The same protocol was repeated 6 months later in order to account for seasonal effects on hair shedding, and the results are reported in this follow-up study. 38 women completed the study. Overall, patients shed an average of 10 to 19 hairs per 60-second interval (range, 1–115). At baseline, patients between the ages of 20–40 years shed an average of 11.6 hairs (SD 8.7), whereas patients between the ages of 41–60 years shed an average of 18.4 hairs (SD 16.9). The difference between these two groups was however not significant at the 5% significance level based on the student’s t-test. Hair counts by the patients and investigators were compatible. At follow-up 6 months later, patients between the ages of 20–40 years shed an average of 9.5 hairs (SD 6.2), whereas patients between the ages of 41-60 years shed an average of 18.5 hairs (SD 16.0). The difference between these two age groups was significant at the 5% significance level based on the student’s t-test. No noticeable seasonal effect on hair shedding was observed. Although there was increased inter-patient variability in hair counts, intra-patient variability was small (ie, individual hair counts were consistent over each of the 3 days.) This is the first study demonstrating the utility of a reproducible, practical, in-home method that will be of use in documenting hair shedding and response to treatment." @default.
• W2043988994 created "2016-06-24" @default.
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• W2043988994 date "2004-03-01" @default.
• W2043988994 modified "2023-09-26" @default.
• W2043988994 title "Results of 60-second timed hair counts in women between the ages of 20–60 years" @default.
• W2043988994 doi "https://doi.org/10.1016/j.jaad.2003.10.297" @default.
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