FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043991690> ?p ?o ?g. }

• W2043991690 endingPage "57" @default.
• W2043991690 startingPage "53" @default.
• W2043991690 abstract "3,3',4,4'-Tetrachlorobiphenyl (TCB) is a known ligand of the Ah-receptor. When TCB was given to Ah-responsive C57BL/6 mice at gestation day 11, 12 or 13, a pattern of embryotoxic effects similar to those of TCDD was produced. This pattern included death and resorptions of the conceptus (peak sensitivity at day 11), as well as characteristic malformations such as cleft palate, dilated kidney pelvis (peak sensitivity day 12), and thymus hypoplasia (peak sensitivity day 13). The ED50 for cleft palate induction was found to be about 100 mg/kg, as compared to 30 micrograms/kg for TCDD (earlier results). The binding affinity of TCB for the Ah-receptor has been reported to be two orders of magnitude lower than that of TCDD. When TCB was introduced into a thymus organ culture (thymi taken from day-14 embryos), the lymphoid cell development was inhibited with an approximate EC50 of 5 X 10(-8) M. This is approximately 100 times higher than that of TCDD and in good agreement with the receptor binding affinities of both compounds. The difference in in vivo toxicity between TCB and TCDD can be explained by a more rapid metabolism and excretion of TCB." @default.
• W2043991690 created "2016-06-24" @default.
• W2043991690 creator A5000782927 @default.
• W2043991690 creator A5049786697 @default.
• W2043991690 creator A5052947911 @default.
• W2043991690 creator A5060697708 @default.
• W2043991690 creator A5068859307 @default.
• W2043991690 creator A5077378029 @default.
• W2043991690 date "1987-07-01" @default.
• W2043991690 modified "2023-10-06" @default.
• W2043991690 title "3,3′,4,4′-Tetrachlorobiphenyl in Pregnant Mice: Embryotoxicity, Teratogenicity, and Toxic Effects on the Cultured Embryonic Thymus" @default.
• W2043991690 cites W1538487545 @default.
• W2043991690 cites W162122792 @default.
• W2043991690 cites W1964775286 @default.
• W2043991690 cites W1988869881 @default.
• W2043991690 cites W1999906583 @default.
• W2043991690 cites W2017832507 @default.
• W2043991690 cites W2019888734 @default.
• W2043991690 cites W2021995588 @default.
• W2043991690 cites W2023666824 @default.
• W2043991690 cites W2043030027 @default.
• W2043991690 cites W2050331936 @default.
• W2043991690 cites W2059514983 @default.
• W2043991690 cites W2059618194 @default.
• W2043991690 cites W2077638622 @default.
• W2043991690 cites W2078193113 @default.
• W2043991690 cites W2082748786 @default.
• W2043991690 cites W2083340603 @default.
• W2043991690 cites W2085130601 @default.
• W2043991690 cites W2092037125 @default.
• W2043991690 cites W2105900692 @default.
• W2043991690 cites W2108184871 @default.
• W2043991690 cites W2122309505 @default.
• W2043991690 cites W2141535774 @default.
• W2043991690 cites W2162067613 @default.
• W2043991690 doi "https://doi.org/10.1111/j.1600-0773.1987.tb01772.x" @default.
• W2043991690 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3114731" @default.
• W2043991690 hasPublicationYear "1987" @default.
• W2043991690 type Work @default.
• W2043991690 sameAs 2043991690 @default.
• W2043991690 citedByCount "28" @default.
• W2043991690 countsByYear W20439916902017 @default.
• W2043991690 crossrefType "journal-article" @default.
• W2043991690 hasAuthorship W2043991690A5000782927 @default.
• W2043991690 hasAuthorship W2043991690A5049786697 @default.
• W2043991690 hasAuthorship W2043991690A5052947911 @default.
• W2043991690 hasAuthorship W2043991690A5060697708 @default.
• W2043991690 hasAuthorship W2043991690A5068859307 @default.
• W2043991690 hasAuthorship W2043991690A5077378029 @default.
• W2043991690 hasConcept C126322002 @default.
• W2043991690 hasConcept C134018914 @default.
• W2043991690 hasConcept C150903083 @default.
• W2043991690 hasConcept C170493617 @default.
• W2043991690 hasConcept C172680121 @default.
• W2043991690 hasConcept C179335377 @default.
• W2043991690 hasConcept C185592680 @default.
• W2043991690 hasConcept C196843134 @default.
• W2043991690 hasConcept C201614185 @default.
• W2043991690 hasConcept C202751555 @default.
• W2043991690 hasConcept C207001950 @default.
• W2043991690 hasConcept C2779234561 @default.
• W2043991690 hasConcept C2780091579 @default.
• W2043991690 hasConcept C29730261 @default.
• W2043991690 hasConcept C32253518 @default.
• W2043991690 hasConcept C42533223 @default.
• W2043991690 hasConcept C46973012 @default.
• W2043991690 hasConcept C54355233 @default.
• W2043991690 hasConcept C55493867 @default.
• W2043991690 hasConcept C65290608 @default.
• W2043991690 hasConcept C71924100 @default.
• W2043991690 hasConcept C86803240 @default.
• W2043991690 hasConcept C95444343 @default.
• W2043991690 hasConcept C96529984 @default.
• W2043991690 hasConceptScore W2043991690C126322002 @default.
• W2043991690 hasConceptScore W2043991690C134018914 @default.
• W2043991690 hasConceptScore W2043991690C150903083 @default.
• W2043991690 hasConceptScore W2043991690C170493617 @default.
• W2043991690 hasConceptScore W2043991690C172680121 @default.
• W2043991690 hasConceptScore W2043991690C179335377 @default.
• W2043991690 hasConceptScore W2043991690C185592680 @default.
• W2043991690 hasConceptScore W2043991690C196843134 @default.
• W2043991690 hasConceptScore W2043991690C201614185 @default.
• W2043991690 hasConceptScore W2043991690C202751555 @default.
• W2043991690 hasConceptScore W2043991690C207001950 @default.
• W2043991690 hasConceptScore W2043991690C2779234561 @default.
• W2043991690 hasConceptScore W2043991690C2780091579 @default.
• W2043991690 hasConceptScore W2043991690C29730261 @default.
• W2043991690 hasConceptScore W2043991690C32253518 @default.
• W2043991690 hasConceptScore W2043991690C42533223 @default.
• W2043991690 hasConceptScore W2043991690C46973012 @default.
• W2043991690 hasConceptScore W2043991690C54355233 @default.
• W2043991690 hasConceptScore W2043991690C55493867 @default.
• W2043991690 hasConceptScore W2043991690C65290608 @default.
• W2043991690 hasConceptScore W2043991690C71924100 @default.
• W2043991690 hasConceptScore W2043991690C86803240 @default.
• W2043991690 hasConceptScore W2043991690C95444343 @default.
• W2043991690 hasConceptScore W2043991690C96529984 @default.
• W2043991690 hasIssue "1" @default.

• next