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- W2043996983 abstract "The dimensions of neuronal dendrites, axons, and synaptic terminals are reproducibly specified for each neuron type, yet it remains unknown how these structures acquire their precise dimensions of length and diameter. Similarly, it remains unknown how active zone number and synaptic strength are specified relative the precise dimensions of presynaptic boutons. In this paper, we demonstrate that S6 kinase (S6K) localizes to the presynaptic active zone. Specifically, S6K colocalizes with the presynaptic protein Bruchpilot (Brp) and requires Brp for active zone localization. We then provide evidence that S6K functions downstream of presynaptic PDK1 to control synaptic bouton size, active zone number, and synaptic function without influencing presynaptic bouton number. We further demonstrate that PDK1 is also a presynaptic protein, though it is distributed more broadly. We present a model in which synaptic S6K responds to local extracellular nutrient and growth factor signaling at the synapse to modulate developmental size specification, including cell size, bouton size, active zone number, and neurotransmitter release." @default.
- W2043996983 created "2016-06-24" @default.
- W2043996983 creator A5002268768 @default.
- W2043996983 creator A5006728364 @default.
- W2043996983 creator A5019656708 @default.
- W2043996983 date "2011-09-19" @default.
- W2043996983 modified "2023-10-11" @default.
- W2043996983 title "S6 kinase localizes to the presynaptic active zone and functions with PDK1 to control synapse development" @default.
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- W2043996983 doi "https://doi.org/10.1083/jcb.201101042" @default.
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