Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044006084> ?p ?o ?g. }
- W2044006084 endingPage "S89" @default.
- W2044006084 startingPage "S85" @default.
- W2044006084 abstract "The hemostatic system plays pleiotropic roles in cancer progression by shaping the tumor microenvironment and metastatic niches through thrombin-dependent fibrin deposition and platelet activation. Expanding experimental evidence implicates coagulation protease receptors expressed by tumor cells as additional players that directly influence tumor biology. Pro-angiogenic G protein-coupled signaling of TF through protease activated receptor 2 and regulation of tumor cell and vascular integrins through ligation by alternative spliced TF are established pathways driving tumor progression. Our recent work shows that the endothelial protein C receptor (EPCR), a stem cell marker in hematopoietic, neuronal and epithelial cells, is also crucial for breast cancer growth in the orthotopic microenvironment of the mammary gland. In aggressive triple-negative breast cancer cells, EPCR expression is a characteristic of cancer stem cell-like populations that have tumor initiating properties in vivo. Blocking antibodies to EPCR attenuate in vivo tumor growth and proliferation specifically of EPCR(+) cells on defined integrin matrices in vitro. We also showed that tumor-associated macrophages are a source for upstream coagulation proteases that can activate TF- and EPCR-dependent cellular responses, suggesting that tumor cells utilize the tumor microenvironment for tumor promoting coagulation protease signaling." @default.
- W2044006084 created "2016-06-24" @default.
- W2044006084 creator A5005286957 @default.
- W2044006084 creator A5050874021 @default.
- W2044006084 date "2014-05-01" @default.
- W2044006084 modified "2023-09-25" @default.
- W2044006084 title "Role of the protein C receptor in cancer progression" @default.
- W2044006084 cites W1561840795 @default.
- W2044006084 cites W1568664552 @default.
- W2044006084 cites W1576346631 @default.
- W2044006084 cites W1732768215 @default.
- W2044006084 cites W173930057 @default.
- W2044006084 cites W1964456661 @default.
- W2044006084 cites W1966846197 @default.
- W2044006084 cites W1969576610 @default.
- W2044006084 cites W1970705657 @default.
- W2044006084 cites W1977649999 @default.
- W2044006084 cites W1984352482 @default.
- W2044006084 cites W1986504153 @default.
- W2044006084 cites W1987200107 @default.
- W2044006084 cites W1990191742 @default.
- W2044006084 cites W1992779737 @default.
- W2044006084 cites W1995387334 @default.
- W2044006084 cites W1997850379 @default.
- W2044006084 cites W1998296919 @default.
- W2044006084 cites W2001627351 @default.
- W2044006084 cites W2008784042 @default.
- W2044006084 cites W2014164476 @default.
- W2044006084 cites W2014716705 @default.
- W2044006084 cites W2015617213 @default.
- W2044006084 cites W2016993995 @default.
- W2044006084 cites W2023316892 @default.
- W2044006084 cites W2023427658 @default.
- W2044006084 cites W2026803473 @default.
- W2044006084 cites W2029539300 @default.
- W2044006084 cites W2029677015 @default.
- W2044006084 cites W2031502809 @default.
- W2044006084 cites W2031770999 @default.
- W2044006084 cites W2034600376 @default.
- W2044006084 cites W2037103210 @default.
- W2044006084 cites W2039568250 @default.
- W2044006084 cites W2039926575 @default.
- W2044006084 cites W2047688072 @default.
- W2044006084 cites W2055792439 @default.
- W2044006084 cites W2056840397 @default.
- W2044006084 cites W2063754581 @default.
- W2044006084 cites W2064693934 @default.
- W2044006084 cites W2066240452 @default.
- W2044006084 cites W2068655393 @default.
- W2044006084 cites W2068773189 @default.
- W2044006084 cites W2070745885 @default.
- W2044006084 cites W2073129389 @default.
- W2044006084 cites W2073759231 @default.
- W2044006084 cites W2074016597 @default.
- W2044006084 cites W2075123115 @default.
- W2044006084 cites W2075829745 @default.
- W2044006084 cites W2078104401 @default.
- W2044006084 cites W2078372594 @default.
- W2044006084 cites W2079428292 @default.
- W2044006084 cites W2080879903 @default.
- W2044006084 cites W2087677741 @default.
- W2044006084 cites W2088627474 @default.
- W2044006084 cites W2090166013 @default.
- W2044006084 cites W2092583562 @default.
- W2044006084 cites W2101137688 @default.
- W2044006084 cites W2101918396 @default.
- W2044006084 cites W2106768579 @default.
- W2044006084 cites W2108883574 @default.
- W2044006084 cites W2110404024 @default.
- W2044006084 cites W2112704241 @default.
- W2044006084 cites W2118186012 @default.
- W2044006084 cites W2119281015 @default.
- W2044006084 cites W2119405901 @default.
- W2044006084 cites W2119739306 @default.
- W2044006084 cites W2125418204 @default.
- W2044006084 cites W2128738080 @default.
- W2044006084 cites W2132472016 @default.
- W2044006084 cites W2135453228 @default.
- W2044006084 cites W2135552434 @default.
- W2044006084 cites W2136178883 @default.
- W2044006084 cites W2137907878 @default.
- W2044006084 cites W2138226936 @default.
- W2044006084 cites W2139005650 @default.
- W2044006084 cites W2141445384 @default.
- W2044006084 cites W2143856136 @default.
- W2044006084 cites W2146508957 @default.
- W2044006084 cites W2146599377 @default.
- W2044006084 cites W2151011478 @default.
- W2044006084 cites W2156329274 @default.
- W2044006084 cites W2160217779 @default.
- W2044006084 cites W2160246910 @default.
- W2044006084 cites W2164143095 @default.
- W2044006084 cites W2191656017 @default.
- W2044006084 cites W9494736 @default.
- W2044006084 doi "https://doi.org/10.1016/s0049-3848(14)50014-x" @default.
- W2044006084 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4270345" @default.
- W2044006084 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24862151" @default.
- W2044006084 hasPublicationYear "2014" @default.