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• W2044010947 abstract "Ghrelin stimulates feeding when administered centrally and peripherally. The lateral hypothalamus (LH) is thought to mediate ghrelin-induced hyperphagia. Thus, we examined central mechanisms underlying feeding generated by LH ghrelin. We determined that 0.3nmol of LH-injected ghrelin was the lowest dose increasing food consumption and it induced Fos immunoreactivity (IR; a marker of neuronal activation) in feeding-related brain areas, including the hypothalamic paraventricular, arcuate, and dorsomedial nuclei, amygdala, and nucleus of the solitary tract. Also, LH ghrelin induced Fos IR in LH orexin neurons. We conclude that the LH, as part of larger central circuitry, integrates orexigenic properties of ghrelin." @default.
• W2044010947 created "2016-06-24" @default.
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• W2044010947 date "2003-04-01" @default.
• W2044010947 modified "2023-10-06" @default.
• W2044010947 title "Neural basis of orexigenic effects of ghrelin acting within lateral hypothalamus" @default.
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• W2044010947 doi "https://doi.org/10.1016/s0196-9781(03)00105-0" @default.
• W2044010947 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12860204" @default.
• W2044010947 hasPublicationYear "2003" @default.
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