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• W2044012809 endingPage "e1658" @default.
• W2044012809 startingPage "e1658" @default.
• W2044012809 abstract "Polycomb (PcG) and trithorax (trxG) genes encode proteins involved in the maintenance of gene expression patterns, notably Hox genes, throughout development. PcG proteins are required for long-term gene repression whereas TrxG proteins are positive regulators that counteract PcG action. PcG and TrxG proteins form large complexes that bind chromatin at overlapping sites called Polycomb and Trithorax Response Elements (PRE/TRE). A third class of proteins, so-called Enhancers of Trithorax and Polycomb (ETP), interacts with either complexes, behaving sometimes as repressors and sometimes as activators. The role of ETP proteins is largely unknown.In a two-hybrid screen, we identified Cyclin G (CycG) as a partner of the Drosophila ETP Corto. Inactivation of CycG by RNA interference highlights its essential role during development. We show here that Corto and CycG directly interact and bind to each other in embryos and S2 cells. Moreover, CycG is targeted to polytene chromosomes where it co-localizes at multiple sites with Corto and with the PcG factor Polyhomeotic (PH). We observed that corto is involved in maintaining Abd-B repression outside its normal expression domain in embryos. This could be achieved by association between Corto and CycG since both proteins bind the regulatory element iab-7 PRE and the promoter of the Abd-B gene.Our results suggest that CycG could regulate the activity of Corto at chromatin and thus be involved in changing Corto from an Enhancer of TrxG into an Enhancer of PcG." @default.
• W2044012809 created "2016-06-24" @default.
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• W2044012809 date "2008-02-20" @default.
• W2044012809 modified "2023-09-25" @default.
• W2044012809 title "The Enhancer of Trithorax and Polycomb Corto Interacts with Cyclin G in Drosophila" @default.
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• W2044012809 doi "https://doi.org/10.1371/journal.pone.0001658" @default.
• W2044012809 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2243016" @default.
• W2044012809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18286205" @default.
• W2044012809 hasPublicationYear "2008" @default.
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