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• W2044015718 abstract "Megakaryopoiesis is associated with inflammatory reactions. To investigate the role of interferon regulatory factors (IRFs) in inflammation-associated megakaryopoiesis, mouse bone marrow hematopoietic stem cells (HSCs) were analyzed. IFN-γ treatment induced IRF-2 expression as well as the expression of CD41 and IRF-1 in HSCs. An in vitro clonogenic assay showed that IRF-2- but not IRF-1-overexpressing cells increased the number of megakaryocytic colonies. IRF-2 transfection up-regulated CD41 promoter activity in hematopoietic cell lines. The number of CD41-positive bone marrow cells increased in mice injected with IRF-2-expressing bone marrow cells. These findings suggest that IRF-2 plays an important role in megakaryopoiesis in inflammatory states." @default.
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• W2044015718 date "2009-10-08" @default.
• W2044015718 modified "2023-09-23" @default.
• W2044015718 title "Interferon regulatory factor-2 induces megakaryopoiesis in mouse bone marrow hematopoietic cells" @default.
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• W2044015718 doi "https://doi.org/10.1016/j.febslet.2009.10.006" @default.
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