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• W2044016062 endingPage "2702" @default.
• W2044016062 startingPage "2697" @default.
• W2044016062 abstract "Multiple myelomas produce tumor-specific antigen (TSA) in the form of idiotype (Id) on monoclonal Ig. CD4(+) T cells can recognize Id-peptide on MHC class II molecules and protect against challenges with MOPC315 cells, which are, as common for myelomas, class II-negative. The present study explains these previous results by demonstrating that Id can be transferred from myeloma cells to antigen-presenting cells (APC), which present processed Id-peptide on their class II molecules to Id-specific T cell receptor-transgenic (TCR-TG) CD4(+) T cells. Id-primed tumor APC were heterogeneous, the majority being dendritic cells with class II(+), CD11b(+) CD11c(+) CD40(+) CD80(+) CD86(+) markers. The APC were localized beneath CD31(+) endothelial cells of tumor microvessels, and their frequency declined with tumor progression. The APC could stimulate Id-specific naive TCR-TG, short-term polarized TCR-TG, and cloned CD4(+) T cells to proliferate and produce cytokines in vitro. Furthermore, small MOPC315 tumors established in Id-specific TCR-TG mice contained clusters of activated (CD69(+)CD25(+)) and proliferating (BrdUrd(+)) Id-specific transgenic CD4(+) blasts. The activated Id-specific T cells were located adjacent to Id-primed dendritic cells in the tumor. Thus, a TSA can be transferred in vivo from myeloma, and possibly other types of cancer cells to APC for MHC class II presentation to CD4(+) T cells." @default.
• W2044016062 created "2016-06-24" @default.
• W2044016062 creator A5033232421 @default.
• W2044016062 creator A5076144155 @default.
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• W2044016062 date "2000-03-07" @default.
• W2044016062 modified "2023-10-17" @default.
• W2044016062 title "Dendritic cells purified from myeloma are primed with tumor-specific antigen (idiotype) and activate CD4⁺T cells" @default.
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• W2044016062 doi "https://doi.org/10.1073/pnas.050579897" @default.
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