FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044032259> ?p ?o ?g. }

• W2044032259 endingPage "109" @default.
• W2044032259 startingPage "93" @default.
• W2044032259 abstract "The important features of cancer cells are uncontrolled growth and proliferation, as well as the ability to metastasis. These features depend mainly on the constant overexpression and activity of various cell signaling proteins, such as signal transducer and activator of transcription 3 (STAT3) and serine–threonine protein kinase AKT proteins. Nitric oxide (NO) has the potential of being anti-tumoral agent, however the exact character of anti-tumoral action of NO is still a matter of debate. In our research we used two NO donors, belonging to NONOates family, with different half-life times: spermine nitric oxide complex hydrate (SPER/NO t1/2 = 39 min) and diethylenetriamine nitric oxide adduct (DETA/NO, t1/2 = 20 h). We evaluated the cytotoxic effect of aforementioned NO donors on SK-OV-3 and OVCAR-3 ovarian cancer cell lines, as well as their effect on posttranslational modification of STAT3 and AKT proteins in these cells. We found that both NO donors present cytotoxic activity on the cancer cell lines, mainly through the induction of apoptosis. What is more, at the high concentration and longer exposure time they were also capable of inducing late apoptosis/necrosis. Both NO donors inhibited STAT3 and AKT3 proteins phosphorylation and down regulated their cytosolic levels, with DETA/NO being stronger inhibitor. We suggests, that NO donors have the potential to act as anti-tumoral agent through inhibiting cancer cell signaling and reducing their viability." @default.
• W2044032259 created "2016-06-24" @default.
• W2044032259 creator A5053383084 @default.
• W2044032259 creator A5068680392 @default.
• W2044032259 creator A5075842117 @default.
• W2044032259 creator A5078635948 @default.
• W2044032259 creator A5079000925 @default.
• W2044032259 date "2013-11-01" @default.
• W2044032259 modified "2023-10-18" @default.
• W2044032259 title "Nitric oxide donors: Spermine/NO and diethylenetriamine/NO induce ovarian cancer cell death and affect STAT3 and AKT signaling proteins" @default.
• W2044032259 cites W145441032 @default.
• W2044032259 cites W1479760463 @default.
• W2044032259 cites W1541492337 @default.
• W2044032259 cites W1943182047 @default.
• W2044032259 cites W1965098193 @default.
• W2044032259 cites W1967663251 @default.
• W2044032259 cites W1968109047 @default.
• W2044032259 cites W1978066824 @default.
• W2044032259 cites W1979877575 @default.
• W2044032259 cites W1980886592 @default.
• W2044032259 cites W1984621921 @default.
• W2044032259 cites W1991545574 @default.
• W2044032259 cites W1992588869 @default.
• W2044032259 cites W1994386857 @default.
• W2044032259 cites W1999468766 @default.
• W2044032259 cites W2007452107 @default.
• W2044032259 cites W2007840001 @default.
• W2044032259 cites W2014087704 @default.
• W2044032259 cites W2014302337 @default.
• W2044032259 cites W2019341050 @default.
• W2044032259 cites W2022458326 @default.
• W2044032259 cites W2023362297 @default.
• W2044032259 cites W2024596145 @default.
• W2044032259 cites W2024945535 @default.
• W2044032259 cites W2026038242 @default.
• W2044032259 cites W2032996948 @default.
• W2044032259 cites W2046798893 @default.
• W2044032259 cites W2046844548 @default.
• W2044032259 cites W2050974084 @default.
• W2044032259 cites W2055450660 @default.
• W2044032259 cites W2058800320 @default.
• W2044032259 cites W2059738518 @default.
• W2044032259 cites W2072754176 @default.
• W2044032259 cites W2072786295 @default.
• W2044032259 cites W2093485019 @default.
• W2044032259 cites W2104550487 @default.
• W2044032259 cites W2106475826 @default.
• W2044032259 cites W2115237069 @default.
• W2044032259 cites W2116628300 @default.
• W2044032259 cites W2120439433 @default.
• W2044032259 cites W2123649025 @default.
• W2044032259 cites W2125933228 @default.
• W2044032259 cites W2128457784 @default.
• W2044032259 cites W2141353482 @default.
• W2044032259 cites W2153439840 @default.
• W2044032259 cites W2168358204 @default.
• W2044032259 cites W2783142245 @default.
• W2044032259 cites W4238567307 @default.
• W2044032259 doi "https://doi.org/10.1016/j.niox.2013.09.001" @default.
• W2044032259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24055735" @default.
• W2044032259 hasPublicationYear "2013" @default.
• W2044032259 type Work @default.
• W2044032259 sameAs 2044032259 @default.
• W2044032259 citedByCount "43" @default.
• W2044032259 countsByYear W20440322592013 @default.
• W2044032259 countsByYear W20440322592014 @default.
• W2044032259 countsByYear W20440322592015 @default.
• W2044032259 countsByYear W20440322592016 @default.
• W2044032259 countsByYear W20440322592017 @default.
• W2044032259 countsByYear W20440322592018 @default.
• W2044032259 countsByYear W20440322592019 @default.
• W2044032259 countsByYear W20440322592020 @default.
• W2044032259 countsByYear W20440322592021 @default.
• W2044032259 countsByYear W20440322592022 @default.
• W2044032259 countsByYear W20440322592023 @default.
• W2044032259 crossrefType "journal-article" @default.
• W2044032259 hasAuthorship W2044032259A5053383084 @default.
• W2044032259 hasAuthorship W2044032259A5068680392 @default.
• W2044032259 hasAuthorship W2044032259A5075842117 @default.
• W2044032259 hasAuthorship W2044032259A5078635948 @default.
• W2044032259 hasAuthorship W2044032259A5079000925 @default.
• W2044032259 hasConcept C121608353 @default.
• W2044032259 hasConcept C154317977 @default.
• W2044032259 hasConcept C171958077 @default.
• W2044032259 hasConcept C178790620 @default.
• W2044032259 hasConcept C181199279 @default.
• W2044032259 hasConcept C185592680 @default.
• W2044032259 hasConcept C190283241 @default.
• W2044032259 hasConcept C202751555 @default.
• W2044032259 hasConcept C2776109719 @default.
• W2044032259 hasConcept C2778923194 @default.
• W2044032259 hasConcept C502942594 @default.
• W2044032259 hasConcept C519581460 @default.
• W2044032259 hasConcept C54355233 @default.
• W2044032259 hasConcept C55493867 @default.
• W2044032259 hasConcept C62478195 @default.
• W2044032259 hasConcept C75217442 @default.
• W2044032259 hasConcept C86554907 @default.

• next