FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044038863> ?p ?o ?g. }

• W2044038863 endingPage "1341" @default.
• W2044038863 startingPage "1331" @default.
• W2044038863 abstract "Abstract Stem cells at the limbus mediate corneal epithelial regeneration and regulate normal tissue homeostasis. Ex vivo cultured limbal epithelial transplantations are being widely practiced in the treatment of limbal stem cell deficiency. In this report, we examined whether the limbal niche cells that nurture and regulate epithelial stem cells coexist in ex vivo limbal cultures. We also compared the inherent differences between explant and suspension culture systems in terms of spatial distribution of niche cells and their effect on epithelial stem cell proliferation, migration, and differentiation in vitro. We report that the stem cell content of both culture systems was similar, explaining the comparable clinical outcomes reported using these two methods. We also showed that the niche cells get expanded in culture and the nestin-positive cells migrate at the leading edges to direct epithelial cell migration in suspension cultures, whereas they are limited to the intact niche in explant cultures. We provide evidence that C/EBPδ-positive, p15-positive, and quiescent, label-retaining, early activated stem cells migrate at the leading edges to regulate epithelial cell proliferation in explant cultures, and this position effect is lost in early suspension cultures. However, in confluent suspension cultures, the stem cells and niche cells interact with each another, migrate in spiraling patterns, and self-organize to form three-dimensional niche-like compartments resembling the limbal crypts and thereby reestablish the position effect. These 3D-sphere clusters are enriched with nestin-, vimentin-, S100-, and p27-positive niche cells and p15-, p21-, p63α-, C/EBPδ-, ABCG2-, and Pax6-positive quiescent epithelial stem cells." @default.
• W2044038863 created "2016-06-24" @default.
• W2044038863 creator A5027451993 @default.
• W2044038863 creator A5031049801 @default.
• W2044038863 creator A5031516095 @default.
• W2044038863 creator A5032471166 @default.
• W2044038863 creator A5047815614 @default.
• W2044038863 creator A5082373685 @default.
• W2044038863 date "2014-09-17" @default.
• W2044038863 modified "2023-10-03" @default.
• W2044038863 title "Spatial Distribution of Niche and Stem Cells in Ex Vivo Human Limbal Cultures" @default.
• W2044038863 cites W1566556117 @default.
• W2044038863 cites W1967479683 @default.
• W2044038863 cites W1973363096 @default.
• W2044038863 cites W1981801628 @default.
• W2044038863 cites W1983328034 @default.
• W2044038863 cites W1985322254 @default.
• W2044038863 cites W1987690014 @default.
• W2044038863 cites W1992744445 @default.
• W2044038863 cites W1999295970 @default.
• W2044038863 cites W2001740094 @default.
• W2044038863 cites W2005501677 @default.
• W2044038863 cites W2012440149 @default.
• W2044038863 cites W2013899958 @default.
• W2044038863 cites W2014001667 @default.
• W2044038863 cites W2014015828 @default.
• W2044038863 cites W2024964552 @default.
• W2044038863 cites W2025937876 @default.
• W2044038863 cites W2036607348 @default.
• W2044038863 cites W2048957342 @default.
• W2044038863 cites W2052802794 @default.
• W2044038863 cites W2065419401 @default.
• W2044038863 cites W2067920606 @default.
• W2044038863 cites W2068367752 @default.
• W2044038863 cites W2068563203 @default.
• W2044038863 cites W2072339252 @default.
• W2044038863 cites W2087438030 @default.
• W2044038863 cites W2088579171 @default.
• W2044038863 cites W2100465544 @default.
• W2044038863 cites W2105974295 @default.
• W2044038863 cites W2119226652 @default.
• W2044038863 cites W2132984034 @default.
• W2044038863 cites W2141231399 @default.
• W2044038863 cites W2144298834 @default.
• W2044038863 cites W2161897762 @default.
• W2044038863 cites W2163035368 @default.
• W2044038863 cites W2168291956 @default.
• W2044038863 doi "https://doi.org/10.5966/sctm.2014-0120" @default.
• W2044038863 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4214849" @default.
• W2044038863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25232182" @default.
• W2044038863 hasPublicationYear "2014" @default.
• W2044038863 type Work @default.
• W2044038863 sameAs 2044038863 @default.
• W2044038863 citedByCount "25" @default.
• W2044038863 countsByYear W20440388632015 @default.
• W2044038863 countsByYear W20440388632016 @default.
• W2044038863 countsByYear W20440388632017 @default.
• W2044038863 countsByYear W20440388632018 @default.
• W2044038863 countsByYear W20440388632019 @default.
• W2044038863 countsByYear W20440388632020 @default.
• W2044038863 countsByYear W20440388632022 @default.
• W2044038863 countsByYear W20440388632023 @default.
• W2044038863 crossrefType "journal-article" @default.
• W2044038863 hasAuthorship W2044038863A5027451993 @default.
• W2044038863 hasAuthorship W2044038863A5031049801 @default.
• W2044038863 hasAuthorship W2044038863A5031516095 @default.
• W2044038863 hasAuthorship W2044038863A5032471166 @default.
• W2044038863 hasAuthorship W2044038863A5047815614 @default.
• W2044038863 hasAuthorship W2044038863A5082373685 @default.
• W2044038863 hasBestOaLocation W20440388631 @default.
• W2044038863 hasConcept C123012128 @default.
• W2044038863 hasConcept C136302470 @default.
• W2044038863 hasConcept C136834591 @default.
• W2044038863 hasConcept C153991713 @default.
• W2044038863 hasConcept C157890192 @default.
• W2044038863 hasConcept C202751555 @default.
• W2044038863 hasConcept C203014093 @default.
• W2044038863 hasConcept C207001950 @default.
• W2044038863 hasConcept C20875687 @default.
• W2044038863 hasConcept C26291073 @default.
• W2044038863 hasConcept C2777738006 @default.
• W2044038863 hasConcept C2778155685 @default.
• W2044038863 hasConcept C2779257441 @default.
• W2044038863 hasConcept C28328180 @default.
• W2044038863 hasConcept C529295009 @default.
• W2044038863 hasConcept C54355233 @default.
• W2044038863 hasConcept C55493867 @default.
• W2044038863 hasConcept C86803240 @default.
• W2044038863 hasConcept C95444343 @default.
• W2044038863 hasConceptScore W2044038863C123012128 @default.
• W2044038863 hasConceptScore W2044038863C136302470 @default.
• W2044038863 hasConceptScore W2044038863C136834591 @default.
• W2044038863 hasConceptScore W2044038863C153991713 @default.
• W2044038863 hasConceptScore W2044038863C157890192 @default.
• W2044038863 hasConceptScore W2044038863C202751555 @default.
• W2044038863 hasConceptScore W2044038863C203014093 @default.
• W2044038863 hasConceptScore W2044038863C207001950 @default.
• W2044038863 hasConceptScore W2044038863C20875687 @default.

• next