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- W2044050871 abstract "Left ventricular filling pressures’ evaluation is still challenging. The ratio of the transmitral and myocardial early diastolic velocities (E/E’) can be used to estimate LV filling pressures (LVFP), but between 8 and 15 it remains unclear. Additionally, the time difference between the onset of E and E’ (Δ (RE-E’)), the time difference between onset of mitral inflow and onset of early diastolic mitral annulus velocity (Δ (IVRT-IVRT’)) and the mitral early diastolic velocity (E)/Strain rate ratio during the isovolumetric relaxation period also correlate to LVFP. The aim of this study was to evaluate the incremental value of those indices to evaluate LVFP (as measured by left ventricular end diastolic pressure (LVEDP)) in a heterogeneous group of patients during a simultaneous invasive procedure. Simultaneous cardiac catheterization, BNP dosage and doppler echocardiography were performed in 30 patients. LVEDP was elevated (>16 mm Hg) in 14 patients (46,7%). The 3 previously described “new” parameters are significantly correlated to LVEDP, but particularly highly significant correlation was found between Δ (IVRT-IVRT’) and LVEDP (r = −0,74, p < 0,005). ROC curves predict a 80% sensibility and specificity of Δ (IVRT-IVRT’). Δ (RE-E’) sensibility and specificity at lateral site are 87% and 93% respectively. E/SRivr has a 71% sensibility and a specificity. The incremental diagnostic value of each parameter and BNP in combination with “classic” parameters (E/A, E/E’) was evaluated by kappa coefficient. Δ (IVRT-IVRT’) at septal site (k = 0,777) and Δ (RE-E’) (k = 0,73) are the most accurate parameters, whereas additional use of E/SRivr (k = 0,41) isn’t more useful than “classic” echocardiographic strategy (k = 0,478) such as BNP (k = 0,533). Δ (IVRT-IVRT’) and Δ (RE-E’) can predict LV filling pressures with reasonable accuracy." @default.
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- W2044050871 date "2011-01-01" @default.
- W2044050871 modified "2023-09-29" @default.
- W2044050871 title "111 “New” echocardiographic isovolumetric parameters combined with standard parameters for the assessment of left ventricular filling pressures" @default.
- W2044050871 doi "https://doi.org/10.1016/s1878-6480(11)70113-6" @default.
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