Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044062856> ?p ?o ?g. }
- W2044062856 endingPage "271" @default.
- W2044062856 startingPage "264" @default.
- W2044062856 abstract "The salmon louse, Lepeophtheirus salmonis, is a parasitic copepod that feeds on the mucus, skin and blood of salmonids. We describe the identification of two complete L. salmonis cathepsin L-like gene sequences and their molecular characterisation. L. salmonis cathepsin L1 (LsCL1), is 978 base pairs in length, encoding a protein of 325 amino acid residues while L. salmonis cathepsin L2 (LsCL2) is 1149 base pairs in length, encoding a protein of 382 amino acid residues. The predicted molecular weights of LsCL1 and LsCL2 are 35,964 Da and 42,150 Da respectively. The two proteases share only 25% identity in the primary sequences; however, the catalytic triad of cysteine, histidine and asparagine is highly conserved for both. Biochemical analysis of L. salmonis extracts revealed that cathepsin L has an optimum activity at pH 6.5, at 15 °C and remains stable at this temperature. Cathepsin L activity is present in all of the parasite life stages assayed, with the chalimus life stage extract exhibiting the most activity. Cathepsin L activity was also observed in the secretory/excretory products possibly indicating a role for this protease in immunoevasion and establishment of the parasite on the host." @default.
- W2044062856 created "2016-06-24" @default.
- W2044062856 creator A5018689764 @default.
- W2044062856 creator A5052399421 @default.
- W2044062856 creator A5052773967 @default.
- W2044062856 creator A5068367604 @default.
- W2044062856 creator A5073970186 @default.
- W2044062856 creator A5076366108 @default.
- W2044062856 creator A5085089819 @default.
- W2044062856 date "2012-08-01" @default.
- W2044062856 modified "2023-09-24" @default.
- W2044062856 title "Cathepsin L proteases of the parasitic copepod, Lepeophtheirus salmonis" @default.
- W2044062856 cites W1491373961 @default.
- W2044062856 cites W1570594131 @default.
- W2044062856 cites W1600346161 @default.
- W2044062856 cites W1759986438 @default.
- W2044062856 cites W1909204218 @default.
- W2044062856 cites W1966284507 @default.
- W2044062856 cites W1972900597 @default.
- W2044062856 cites W1973272261 @default.
- W2044062856 cites W1974073103 @default.
- W2044062856 cites W1977825889 @default.
- W2044062856 cites W1986183660 @default.
- W2044062856 cites W1989667549 @default.
- W2044062856 cites W1998469878 @default.
- W2044062856 cites W2005732958 @default.
- W2044062856 cites W2009972285 @default.
- W2044062856 cites W2015089055 @default.
- W2044062856 cites W2016306196 @default.
- W2044062856 cites W2032712087 @default.
- W2044062856 cites W2038166186 @default.
- W2044062856 cites W2040473035 @default.
- W2044062856 cites W2041923914 @default.
- W2044062856 cites W2046054680 @default.
- W2044062856 cites W2048903762 @default.
- W2044062856 cites W2055773208 @default.
- W2044062856 cites W2061244340 @default.
- W2044062856 cites W2063601424 @default.
- W2044062856 cites W2073684122 @default.
- W2044062856 cites W2078909963 @default.
- W2044062856 cites W2088820312 @default.
- W2044062856 cites W2092275783 @default.
- W2044062856 cites W2094123127 @default.
- W2044062856 cites W2100220440 @default.
- W2044062856 cites W2102424972 @default.
- W2044062856 cites W2106882534 @default.
- W2044062856 cites W2131693276 @default.
- W2044062856 cites W2150840749 @default.
- W2044062856 cites W2162162951 @default.
- W2044062856 cites W2169872465 @default.
- W2044062856 cites W2171777269 @default.
- W2044062856 cites W2173882015 @default.
- W2044062856 cites W40008902 @default.
- W2044062856 cites W4252823753 @default.
- W2044062856 cites W2011090400 @default.
- W2044062856 doi "https://doi.org/10.1016/j.aquaculture.2012.05.007" @default.
- W2044062856 hasPublicationYear "2012" @default.
- W2044062856 type Work @default.
- W2044062856 sameAs 2044062856 @default.
- W2044062856 citedByCount "16" @default.
- W2044062856 countsByYear W20440628562013 @default.
- W2044062856 countsByYear W20440628562014 @default.
- W2044062856 countsByYear W20440628562015 @default.
- W2044062856 countsByYear W20440628562016 @default.
- W2044062856 countsByYear W20440628562017 @default.
- W2044062856 countsByYear W20440628562019 @default.
- W2044062856 countsByYear W20440628562020 @default.
- W2044062856 countsByYear W20440628562021 @default.
- W2044062856 countsByYear W20440628562022 @default.
- W2044062856 countsByYear W20440628562023 @default.
- W2044062856 crossrefType "journal-article" @default.
- W2044062856 hasAuthorship W2044062856A5018689764 @default.
- W2044062856 hasAuthorship W2044062856A5052399421 @default.
- W2044062856 hasAuthorship W2044062856A5052773967 @default.
- W2044062856 hasAuthorship W2044062856A5068367604 @default.
- W2044062856 hasAuthorship W2044062856A5073970186 @default.
- W2044062856 hasAuthorship W2044062856A5076366108 @default.
- W2044062856 hasAuthorship W2044062856A5085089819 @default.
- W2044062856 hasConcept C136764020 @default.
- W2044062856 hasConcept C145734084 @default.
- W2044062856 hasConcept C167844969 @default.
- W2044062856 hasConcept C174937957 @default.
- W2044062856 hasConcept C181199279 @default.
- W2044062856 hasConcept C182220744 @default.
- W2044062856 hasConcept C2776714187 @default.
- W2044062856 hasConcept C2777283782 @default.
- W2044062856 hasConcept C2780034444 @default.
- W2044062856 hasConcept C2780253540 @default.
- W2044062856 hasConcept C28021979 @default.
- W2044062856 hasConcept C2909208804 @default.
- W2044062856 hasConcept C34695024 @default.
- W2044062856 hasConcept C41008148 @default.
- W2044062856 hasConcept C505870484 @default.
- W2044062856 hasConcept C515207424 @default.
- W2044062856 hasConcept C55493867 @default.
- W2044062856 hasConcept C71928629 @default.
- W2044062856 hasConcept C86803240 @default.
- W2044062856 hasConcept C86909935 @default.