FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044068573> ?p ?o ?g. }

• W2044068573 endingPage "320" @default.
• W2044068573 startingPage "313" @default.
• W2044068573 abstract "The aim of this study was to evaluate new ligands which can be applied for labeling biomolecules with scandium radionuclides. Two radionuclides of scandium, 47Sc and 44Sc, are perspective radioisotopes for radiotherapy and diagnostic imaging. 47Sc decays with a half-life of 3.35 days and a maximum β− energy of 600 keV and could be an alternative to carrier added 177Lu radionuclide for targeted radionuclide therapy. Another scandium radionuclide 44Sc (t1/2 = 3.92 h) is an ideal β+ emitter for PET diagnosis. It can be obtained as a daughter of the long-lived 44Ti (t1/2 = 60.4 y) from 44Ti/44Sc generator. For complexation of scandium radionuclides macrocyclic ligands having a cavity size similar to Sc3+ ionic radius were selected: 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), 1,4,7-triazacyclononane-1,4,7 triacetic acid (NOTA), 1,4,7-triazacyclodecane-1,4,7 triacetic acid and 1,4,7-triazacycloundecane triacetic acid, and analogs of NOTA with 10, 11 and 12 atoms of the carbon in the ring. Our results have shown that from the studied macrocyclic ligands studied DOTA is most efficient for binding scandium radionuclides 44Sc and 47Sc to biomolecules. The determined stability constant of Sc–DOTA complex logK = 27.0 is comparable with stability constants for Y3+ and heaviest lanthanides but is higher than those for In3+ and Ga3+. Also 46Sc-DOTATATE conjugate exhibits high stability in-vitro studies. The 13C NMR studies have shown that Sc–DOTA like Lu–DOTA forms in solution complexes with eight-coordination geometry. The lipophilicity of Sc-DOTATATE is nearly identical to that of Lu-DOTATATE, which suggests similar receptor affinity of both radioconjugates." @default.
• W2044068573 created "2016-06-24" @default.
• W2044068573 creator A5045750178 @default.
• W2044068573 creator A5065834633 @default.
• W2044068573 date "2011-02-01" @default.
• W2044068573 modified "2023-10-03" @default.
• W2044068573 title "Macrocyclic complexes of scandium radionuclides as precursors for diagnostic and therapeutic radiopharmaceuticals" @default.
• W2044068573 cites W1966813721 @default.
• W2044068573 cites W1971011523 @default.
• W2044068573 cites W1971573704 @default.
• W2044068573 cites W1972294103 @default.
• W2044068573 cites W1972332231 @default.
• W2044068573 cites W1976792913 @default.
• W2044068573 cites W1977565605 @default.
• W2044068573 cites W1978818400 @default.
• W2044068573 cites W1983714582 @default.
• W2044068573 cites W1988343209 @default.
• W2044068573 cites W1989898634 @default.
• W2044068573 cites W1993365120 @default.
• W2044068573 cites W1995978914 @default.
• W2044068573 cites W2000305459 @default.
• W2044068573 cites W2005674134 @default.
• W2044068573 cites W2016280328 @default.
• W2044068573 cites W2021137787 @default.
• W2044068573 cites W2032269296 @default.
• W2044068573 cites W2034711346 @default.
• W2044068573 cites W2035921201 @default.
• W2044068573 cites W2036044644 @default.
• W2044068573 cites W2036361071 @default.
• W2044068573 cites W2044603294 @default.
• W2044068573 cites W2075383063 @default.
• W2044068573 cites W2075789686 @default.
• W2044068573 cites W2077821054 @default.
• W2044068573 cites W2095734930 @default.
• W2044068573 cites W2109835798 @default.
• W2044068573 cites W2119643174 @default.
• W2044068573 cites W2121521155 @default.
• W2044068573 cites W2128440430 @default.
• W2044068573 cites W2128544796 @default.
• W2044068573 cites W2137892677 @default.
• W2044068573 cites W2151230949 @default.
• W2044068573 cites W2152862781 @default.
• W2044068573 cites W2167590372 @default.
• W2044068573 cites W2168853945 @default.
• W2044068573 cites W2951184700 @default.
• W2044068573 cites W2952456649 @default.
• W2044068573 doi "https://doi.org/10.1016/j.jinorgbio.2010.11.003" @default.
• W2044068573 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21194633" @default.
• W2044068573 hasPublicationYear "2011" @default.
• W2044068573 type Work @default.
• W2044068573 sameAs 2044068573 @default.
• W2044068573 citedByCount "110" @default.
• W2044068573 countsByYear W20440685732012 @default.
• W2044068573 countsByYear W20440685732013 @default.
• W2044068573 countsByYear W20440685732014 @default.
• W2044068573 countsByYear W20440685732015 @default.
• W2044068573 countsByYear W20440685732016 @default.
• W2044068573 countsByYear W20440685732017 @default.
• W2044068573 countsByYear W20440685732018 @default.
• W2044068573 countsByYear W20440685732019 @default.
• W2044068573 countsByYear W20440685732020 @default.
• W2044068573 countsByYear W20440685732021 @default.
• W2044068573 countsByYear W20440685732022 @default.
• W2044068573 countsByYear W20440685732023 @default.
• W2044068573 crossrefType "journal-article" @default.
• W2044068573 hasAuthorship W2044068573A5045750178 @default.
• W2044068573 hasAuthorship W2044068573A5065834633 @default.
• W2044068573 hasConcept C121332964 @default.
• W2044068573 hasConcept C13965031 @default.
• W2044068573 hasConcept C145148216 @default.
• W2044068573 hasConcept C158973077 @default.
• W2044068573 hasConcept C177322064 @default.
• W2044068573 hasConcept C178790620 @default.
• W2044068573 hasConcept C179104552 @default.
• W2044068573 hasConcept C185592680 @default.
• W2044068573 hasConcept C197404232 @default.
• W2044068573 hasConcept C2777459166 @default.
• W2044068573 hasConcept C2779931791 @default.
• W2044068573 hasConcept C2989005 @default.
• W2044068573 hasConcept C2993559085 @default.
• W2044068573 hasConcept C54998646 @default.
• W2044068573 hasConcept C551831248 @default.
• W2044068573 hasConcept C62520636 @default.
• W2044068573 hasConcept C71240020 @default.
• W2044068573 hasConcept C71924100 @default.
• W2044068573 hasConceptScore W2044068573C121332964 @default.
• W2044068573 hasConceptScore W2044068573C13965031 @default.
• W2044068573 hasConceptScore W2044068573C145148216 @default.
• W2044068573 hasConceptScore W2044068573C158973077 @default.
• W2044068573 hasConceptScore W2044068573C177322064 @default.
• W2044068573 hasConceptScore W2044068573C178790620 @default.
• W2044068573 hasConceptScore W2044068573C179104552 @default.
• W2044068573 hasConceptScore W2044068573C185592680 @default.
• W2044068573 hasConceptScore W2044068573C197404232 @default.
• W2044068573 hasConceptScore W2044068573C2777459166 @default.
• W2044068573 hasConceptScore W2044068573C2779931791 @default.
• W2044068573 hasConceptScore W2044068573C2989005 @default.
• W2044068573 hasConceptScore W2044068573C2993559085 @default.

• next