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• W2044080558 startingPage "30" @default.
• W2044080558 abstract "Clostridium sordellii produces two toxins, designated HT (haemorrhagic toxin) and LT (lethal toxin), that are similar to toxins A and B of C. difficile. The physicochemical properties of toxins HT and A were remarkably similar. The specific biological activities of toxin HT were almost the same as those of toxin A, and their NH2-terminal sequences shared close homology. The properties of toxins LT and B were similar, as were their NH2-terminal sequences, but toxin B was much more cytotoxic than toxin LT. Immunodiffusion analysis with specific antibodies showed that although toxins B and LT shared major antigenic determinants, each had unique epitopes. The results suggest that toxins B and LT have diverged more than toxins A and HT. Immunoblotting with antibodies to the toxins of C. difficile showed that toxins HT and LT had common antigenic determinants." @default.
• W2044080558 created "2016-06-24" @default.
• W2044080558 creator A5057297270 @default.
• W2044080558 creator A5073283117 @default.
• W2044080558 date "1992-01-01" @default.
• W2044080558 modified "2023-09-23" @default.
• W2044080558 title "Comparison of Clostridium sordellii toxins HT and LT with toxins A and B of C. difficile" @default.
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• W2044080558 doi "https://doi.org/10.1099/00222615-36-1-30" @default.
• W2044080558 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1370542" @default.
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