FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044081025> ?p ?o ?g. }

• W2044081025 endingPage "e839" @default.
• W2044081025 startingPage "e839" @default.
• W2044081025 abstract "The pathways of reactive oxygen species (ROS)-mediated apoptosis induction, of Bax activation and the sensitization of tumor cells for TRAIL (TNF-related apoptosis-inducing ligand)-induced apoptosis are still largely elusive. Here, sensitization of melanoma cells for TRAIL by the PI3-kinase inhibitor wortmannin correlated to the activation of mitochondrial apoptosis pathways. Apoptosis was dependent on Bax and abrogated by Bcl-2 overexpression. The synergistic enhancement was explained by Bax activation through wortmannin, which tightly correlated to the characteristic Bax phosphorylation patterns. Thus, wortmannin resulted in early reduction of the Bax-inactivating phosphorylation at serine-184, whereas the Bax-activating phosphorylation at threonine-167 was enhanced. Proving the responsibility of the pathway, comparable effects were obtained with an Akt inhibitor (MK-2206); while suppressed phosphorylation of serine-184 may be attributed to reduced Akt activity itself, the causes of enhanced threonine-167 phosphorylation were addressed here. Characteristically, production of ROS was seen early in response to wortmannin and MK-2206. Providing the link between ROS and Bax, we show that abrogated ROS production by α -tocopherol or by NADPH oxidase 4 (NOX4) siRNA suppressed apoptosis and Bax activation. This correlated with reduced Bax phosphorylation at threonine-167. The data unraveled a mechanism by which NOX4-dependent ROS production controls apoptosis via Bax phosphorylation. The pathway may be considered for proapoptotic, anticancer strategies." @default.
• W2044081025 created "2016-06-24" @default.
• W2044081025 creator A5029406176 @default.
• W2044081025 creator A5063624774 @default.
• W2044081025 creator A5079622613 @default.
• W2044081025 date "2013-10-10" @default.
• W2044081025 modified "2023-10-06" @default.
• W2044081025 title "ROS-dependent phosphorylation of Bax by wortmannin sensitizes melanoma cells for TRAIL-induced apoptosis" @default.
• W2044081025 cites W1484817497 @default.
• W2044081025 cites W1964302525 @default.
• W2044081025 cites W1965259410 @default.
• W2044081025 cites W1972553211 @default.
• W2044081025 cites W1972983970 @default.
• W2044081025 cites W1977258127 @default.
• W2044081025 cites W1980345051 @default.
• W2044081025 cites W1980447537 @default.
• W2044081025 cites W1980621837 @default.
• W2044081025 cites W1982861164 @default.
• W2044081025 cites W1982908434 @default.
• W2044081025 cites W1986396787 @default.
• W2044081025 cites W1986722992 @default.
• W2044081025 cites W1986725538 @default.
• W2044081025 cites W1987334812 @default.
• W2044081025 cites W1991959249 @default.
• W2044081025 cites W1995168336 @default.
• W2044081025 cites W2009364489 @default.
• W2044081025 cites W2011383001 @default.
• W2044081025 cites W2020309430 @default.
• W2044081025 cites W2020547407 @default.
• W2044081025 cites W2028301924 @default.
• W2044081025 cites W2032099289 @default.
• W2044081025 cites W2032860349 @default.
• W2044081025 cites W2036411709 @default.
• W2044081025 cites W2038118195 @default.
• W2044081025 cites W2049005145 @default.
• W2044081025 cites W2051972593 @default.
• W2044081025 cites W2057546011 @default.
• W2044081025 cites W2063154392 @default.
• W2044081025 cites W2066571367 @default.
• W2044081025 cites W2076269247 @default.
• W2044081025 cites W2079347375 @default.
• W2044081025 cites W2081185975 @default.
• W2044081025 cites W2085128107 @default.
• W2044081025 cites W2087366222 @default.
• W2044081025 cites W2087650169 @default.
• W2044081025 cites W2089784158 @default.
• W2044081025 cites W2093448823 @default.
• W2044081025 cites W2093557429 @default.
• W2044081025 cites W2096009033 @default.
• W2044081025 cites W2106292206 @default.
• W2044081025 cites W2107772775 @default.
• W2044081025 cites W2112768034 @default.
• W2044081025 cites W2113211717 @default.
• W2044081025 cites W2121729112 @default.
• W2044081025 cites W2126917392 @default.
• W2044081025 cites W2127324182 @default.
• W2044081025 cites W2133221875 @default.
• W2044081025 cites W2134299232 @default.
• W2044081025 cites W2140442678 @default.
• W2044081025 cites W2142911981 @default.
• W2044081025 cites W2146825351 @default.
• W2044081025 cites W2148342786 @default.
• W2044081025 cites W2148460489 @default.
• W2044081025 cites W2156078931 @default.
• W2044081025 cites W2161861008 @default.
• W2044081025 cites W2330709458 @default.
• W2044081025 doi "https://doi.org/10.1038/cddis.2013.344" @default.
• W2044081025 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3824654" @default.
• W2044081025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24113173" @default.
• W2044081025 hasPublicationYear "2013" @default.
• W2044081025 type Work @default.
• W2044081025 sameAs 2044081025 @default.
• W2044081025 citedByCount "71" @default.
• W2044081025 countsByYear W20440810252014 @default.
• W2044081025 countsByYear W20440810252015 @default.
• W2044081025 countsByYear W20440810252016 @default.
• W2044081025 countsByYear W20440810252017 @default.
• W2044081025 countsByYear W20440810252018 @default.
• W2044081025 countsByYear W20440810252019 @default.
• W2044081025 countsByYear W20440810252020 @default.
• W2044081025 countsByYear W20440810252021 @default.
• W2044081025 countsByYear W20440810252022 @default.
• W2044081025 countsByYear W20440810252023 @default.
• W2044081025 crossrefType "journal-article" @default.
• W2044081025 hasAuthorship W2044081025A5029406176 @default.
• W2044081025 hasAuthorship W2044081025A5063624774 @default.
• W2044081025 hasAuthorship W2044081025A5079622613 @default.
• W2044081025 hasBestOaLocation W20440810251 @default.
• W2044081025 hasConcept C11960822 @default.
• W2044081025 hasConcept C184235292 @default.
• W2044081025 hasConcept C185592680 @default.
• W2044081025 hasConcept C190283241 @default.
• W2044081025 hasConcept C2776912716 @default.
• W2044081025 hasConcept C2778308172 @default.
• W2044081025 hasConcept C48349386 @default.
• W2044081025 hasConcept C55493867 @default.
• W2044081025 hasConcept C62478195 @default.
• W2044081025 hasConcept C75217442 @default.

• next