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• W2044094920 abstract "The dorsal-ventral polarity of the somite is controlled by antagonistic signals from the dorsal neural tube/surface ectoderm, mediated by WNTs, and from the ventral notochord, mediated by sonic hedgehog (SHH). Each factor can act over a distance greater than a somite diameter in vitro, suggesting they must limit each other's actions within their own patterning domains in vivo. We show here that the growth-arrest specific gene 1 (Gas1), which is expressed in the dorsal somite, is induced by WNTs and encodes a protein that can bind to SHH. Furthermore, ectopic expression of Gas1 in presomitic cells attenuates the response of these cells to SHH in vitro. Taken together, these data suggest that GAS1 functions to reduce the availability of active SHH within the dorsal somite." @default.
• W2044094920 created "2016-06-24" @default.
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• W2044094920 date "2001-09-25" @default.
• W2044094920 modified "2023-10-02" @default.
• W2044094920 title "Evidence that the WNT-inducible <i>growth arrest-specific gene 1</i> encodes an antagonist of sonic hedgehog signaling in the somite" @default.
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• W2044094920 doi "https://doi.org/10.1073/pnas.201418298" @default.
• W2044094920 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/58732" @default.
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