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- W2044095148 abstract "Summary Immune thrombocytopenic purpura (ITP) is mediated by antiplatelet autoantibodies possibly involving CD40:CD40L co‐stimulation. Two humanized anti‐CD40L monoclonal antibodies, hu5c8 and IDEC‐131, were evaluated in 46 patients with chronic refractory ITP. Fifteen patients were treated with 20 mg/kg of hu5c8: four (27%) had complete responses (CR) and two (13%) had partial responses (PR). Three responders to hu5c8 were successfully retreated with IDEC‐131, demonstrating its efficacy. Thirty‐one subsequent patients were treated with 5–20 mg/kg per infusion of IDEC‐131: five (16%) responded (one CR and four PR). The 24% (11/46) overall response rate demonstrates the potential role of CD40‐CD40L in the pathogenesis of ITP." @default.
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- W2044095148 date "2008-03-27" @default.
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- W2044095148 title "The effect of anti-CD40 ligand in immune thrombocytopenic purpura" @default.
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- W2044095148 doi "https://doi.org/10.1111/j.1365-2141.2008.07039.x" @default.
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