Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044095917> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2044095917 endingPage "20" @default.
- W2044095917 startingPage "14" @default.
- W2044095917 abstract "The present study examined the efficacy and tolerability of acute escitalopram treatment in depressed patients aged 60 years or older.Patients aged > or =60 years with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition major depressive disorder were randomized to 12 weeks of double-blind, flexible-dose treatment with escitalopram (10-20 mg/day; N = 130) or placebo (N = 134). The prospectively defined primary efficacy end point was change from baseline to week 12 in Montgomery-Asberg Depression Rating Scale (MADRS) total score using the last observation carried forward approach.A total of 109 (81%) patients in the placebo group and 96 (74%) patients in the escitalopram group completed treatment. Mean age in both groups was approximately 68 years. Mean baseline MADRS scores were 28.4 and 29.4 for the placebo and escitalopram treatment groups, respectively. Escitalopram did not achieve statistical significance compared with placebo in change from baseline on the MADRS (least square mean difference: -1.34; last observation carried forward). Discontinuation rates resulting from adverse events were 6% for placebo and 11% for escitalopram. Treatment-emergent adverse events reported by >10% of patients in the escitalopram group were headache, nausea, diarrhea, and dry mouth.Escitalopram treatment was not significantly different from placebo treatment on the primary efficacy measure, change from baseline to week 12 in MADRS. In patients aged 60 years or older with major depression, acute escitalopram treatment appeared to be well tolerated." @default.
- W2044095917 created "2016-06-24" @default.
- W2044095917 creator A5017921825 @default.
- W2044095917 creator A5023885494 @default.
- W2044095917 creator A5027777637 @default.
- W2044095917 date "2008-01-01" @default.
- W2044095917 modified "2023-09-30" @default.
- W2044095917 title "Escitalopram in the Acute Treatment of Depressed Patients Aged 60 Years or Older" @default.
- W2044095917 cites W1994862345 @default.
- W2044095917 cites W2045775503 @default.
- W2044095917 cites W2046456855 @default.
- W2044095917 cites W2061469903 @default.
- W2044095917 cites W2080229560 @default.
- W2044095917 cites W2095641460 @default.
- W2044095917 cites W2124640962 @default.
- W2044095917 cites W2137785805 @default.
- W2044095917 cites W2155363339 @default.
- W2044095917 cites W2160008980 @default.
- W2044095917 cites W2417565473 @default.
- W2044095917 cites W4253158066 @default.
- W2044095917 cites W4297914005 @default.
- W2044095917 doi "https://doi.org/10.1097/jgp.0b013e3181591c09" @default.
- W2044095917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18165459" @default.
- W2044095917 hasPublicationYear "2008" @default.
- W2044095917 type Work @default.
- W2044095917 sameAs 2044095917 @default.
- W2044095917 citedByCount "98" @default.
- W2044095917 countsByYear W20440959172012 @default.
- W2044095917 countsByYear W20440959172013 @default.
- W2044095917 countsByYear W20440959172014 @default.
- W2044095917 countsByYear W20440959172015 @default.
- W2044095917 countsByYear W20440959172016 @default.
- W2044095917 countsByYear W20440959172017 @default.
- W2044095917 countsByYear W20440959172018 @default.
- W2044095917 countsByYear W20440959172019 @default.
- W2044095917 countsByYear W20440959172020 @default.
- W2044095917 countsByYear W20440959172021 @default.
- W2044095917 countsByYear W20440959172022 @default.
- W2044095917 countsByYear W20440959172023 @default.
- W2044095917 crossrefType "journal-article" @default.
- W2044095917 hasAuthorship W2044095917A5017921825 @default.
- W2044095917 hasAuthorship W2044095917A5023885494 @default.
- W2044095917 hasAuthorship W2044095917A5027777637 @default.
- W2044095917 hasConcept C118552586 @default.
- W2044095917 hasConcept C126322002 @default.
- W2044095917 hasConcept C142724271 @default.
- W2044095917 hasConcept C15744967 @default.
- W2044095917 hasConcept C168563851 @default.
- W2044095917 hasConcept C197934379 @default.
- W2044095917 hasConcept C204787440 @default.
- W2044095917 hasConcept C27081682 @default.
- W2044095917 hasConcept C2778375690 @default.
- W2044095917 hasConcept C2778715236 @default.
- W2044095917 hasConcept C2779144063 @default.
- W2044095917 hasConcept C2779177272 @default.
- W2044095917 hasConcept C2779583969 @default.
- W2044095917 hasConcept C2780051608 @default.
- W2044095917 hasConcept C2780580376 @default.
- W2044095917 hasConcept C558461103 @default.
- W2044095917 hasConcept C71924100 @default.
- W2044095917 hasConceptScore W2044095917C118552586 @default.
- W2044095917 hasConceptScore W2044095917C126322002 @default.
- W2044095917 hasConceptScore W2044095917C142724271 @default.
- W2044095917 hasConceptScore W2044095917C15744967 @default.
- W2044095917 hasConceptScore W2044095917C168563851 @default.
- W2044095917 hasConceptScore W2044095917C197934379 @default.
- W2044095917 hasConceptScore W2044095917C204787440 @default.
- W2044095917 hasConceptScore W2044095917C27081682 @default.
- W2044095917 hasConceptScore W2044095917C2778375690 @default.
- W2044095917 hasConceptScore W2044095917C2778715236 @default.
- W2044095917 hasConceptScore W2044095917C2779144063 @default.
- W2044095917 hasConceptScore W2044095917C2779177272 @default.
- W2044095917 hasConceptScore W2044095917C2779583969 @default.
- W2044095917 hasConceptScore W2044095917C2780051608 @default.
- W2044095917 hasConceptScore W2044095917C2780580376 @default.
- W2044095917 hasConceptScore W2044095917C558461103 @default.
- W2044095917 hasConceptScore W2044095917C71924100 @default.
- W2044095917 hasIssue "1" @default.
- W2044095917 hasLocation W20440959171 @default.
- W2044095917 hasLocation W20440959172 @default.
- W2044095917 hasOpenAccess W2044095917 @default.
- W2044095917 hasPrimaryLocation W20440959171 @default.
- W2044095917 hasRelatedWork W137885780 @default.
- W2044095917 hasRelatedWork W1982089628 @default.
- W2044095917 hasRelatedWork W1995650316 @default.
- W2044095917 hasRelatedWork W2007323411 @default.
- W2044095917 hasRelatedWork W2035049801 @default.
- W2044095917 hasRelatedWork W2438976023 @default.
- W2044095917 hasRelatedWork W3023502736 @default.
- W2044095917 hasRelatedWork W4297914005 @default.
- W2044095917 hasRelatedWork W4306722605 @default.
- W2044095917 hasRelatedWork W2183331092 @default.
- W2044095917 hasVolume "16" @default.
- W2044095917 isParatext "false" @default.
- W2044095917 isRetracted "false" @default.
- W2044095917 magId "2044095917" @default.
- W2044095917 workType "article" @default.