Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044101547> ?p ?o ?g. }
- W2044101547 endingPage "1087" @default.
- W2044101547 startingPage "1077" @default.
- W2044101547 abstract "Genes associated with energy metabolism are decreased in schizophrenia brain and human and rodent diabetic skeletal muscle. These and other similarities between diabetes and schizophrenia suggest that an insulin signaling deficit may underlie schizophrenia. We determined with human SH-SY5Y neuroblastoma and astrocyte cell lines whether insulin or other molecules could modulate genes opposite to their change reported in schizophrenia brain.Both cell lines were treated with insulin, insulin-like growth factor (IGF)-1, IGF-2, or brain-derived neurotrophic factor (BDNF). Genes whose expression was found with microarrays to be changed by insulin in a reciprocal manner to their change in schizophrenia were used in a 16-gene miniarray to identify small molecules that might mimic insulin.Insulin phosphorylated its receptor in the neuroblastoma cells but not in astrocytes and, like IGF-1, increased ERK1/2 and Akt phosphorylation. Insulin and IGF-1 increased the expression of genes decreased in schizophrenia, including those involved in mitochondrial functions, glucose and energy metabolism, hydrogen ion transport, and synaptic function. These gene effects were confirmed and shown to be dose related with the 16-gene miniarrays. Most of 1940 pharmacologically unique compounds failed to alter gene expression, with the exception of muscarinic agonists, which mimicked insulin and IGF-1, and which were blocked by the muscarinic antagonists atropine and telenzepine.Stimulation of muscarinic and insulin/IGF-1 receptors alter genes associated with metabolic and synaptic functions in a manner reciprocal to their changes in schizophrenia. Pharmacologic activation of these receptors may normalize genomic alterations in schizophrenia and better address root causes of this disease." @default.
- W2044101547 created "2016-06-24" @default.
- W2044101547 creator A5000843014 @default.
- W2044101547 creator A5010426134 @default.
- W2044101547 creator A5020505455 @default.
- W2044101547 creator A5023640237 @default.
- W2044101547 creator A5034635891 @default.
- W2044101547 creator A5065605797 @default.
- W2044101547 creator A5069615450 @default.
- W2044101547 creator A5073415869 @default.
- W2044101547 creator A5086401674 @default.
- W2044101547 date "2008-12-01" @default.
- W2044101547 modified "2023-09-24" @default.
- W2044101547 title "Insulin, IGF-1, and Muscarinic Agonists Modulate Schizophrenia-associated Genes in Human Neuroblastoma Cells" @default.
- W2044101547 cites W1536927042 @default.
- W2044101547 cites W1542898773 @default.
- W2044101547 cites W1590376803 @default.
- W2044101547 cites W1732798991 @default.
- W2044101547 cites W1965403083 @default.
- W2044101547 cites W1966715142 @default.
- W2044101547 cites W1967684178 @default.
- W2044101547 cites W1969804821 @default.
- W2044101547 cites W1972764203 @default.
- W2044101547 cites W1973584991 @default.
- W2044101547 cites W1976834251 @default.
- W2044101547 cites W1978703935 @default.
- W2044101547 cites W1982806869 @default.
- W2044101547 cites W1984120803 @default.
- W2044101547 cites W1995361556 @default.
- W2044101547 cites W1995491925 @default.
- W2044101547 cites W1995540460 @default.
- W2044101547 cites W1997089281 @default.
- W2044101547 cites W2003299840 @default.
- W2044101547 cites W2004066915 @default.
- W2044101547 cites W2010531955 @default.
- W2044101547 cites W2013173630 @default.
- W2044101547 cites W2013224236 @default.
- W2044101547 cites W2014260646 @default.
- W2044101547 cites W2017577100 @default.
- W2044101547 cites W2032208151 @default.
- W2044101547 cites W2035854501 @default.
- W2044101547 cites W2036398723 @default.
- W2044101547 cites W2041893385 @default.
- W2044101547 cites W2046140548 @default.
- W2044101547 cites W2046945103 @default.
- W2044101547 cites W2049871798 @default.
- W2044101547 cites W2050640058 @default.
- W2044101547 cites W2051221009 @default.
- W2044101547 cites W2052502735 @default.
- W2044101547 cites W2055782708 @default.
- W2044101547 cites W2057014456 @default.
- W2044101547 cites W2057251357 @default.
- W2044101547 cites W2059786395 @default.
- W2044101547 cites W2062009247 @default.
- W2044101547 cites W2067418199 @default.
- W2044101547 cites W2072226762 @default.
- W2044101547 cites W2079453546 @default.
- W2044101547 cites W2079587879 @default.
- W2044101547 cites W2083394776 @default.
- W2044101547 cites W2084761782 @default.
- W2044101547 cites W2086661709 @default.
- W2044101547 cites W2090854696 @default.
- W2044101547 cites W2092638493 @default.
- W2044101547 cites W2092846791 @default.
- W2044101547 cites W2103515488 @default.
- W2044101547 cites W2104102972 @default.
- W2044101547 cites W2112211965 @default.
- W2044101547 cites W2112835137 @default.
- W2044101547 cites W2113083842 @default.
- W2044101547 cites W2114272370 @default.
- W2044101547 cites W2115039568 @default.
- W2044101547 cites W2116680356 @default.
- W2044101547 cites W2116721266 @default.
- W2044101547 cites W2117217305 @default.
- W2044101547 cites W2121082411 @default.
- W2044101547 cites W2123106337 @default.
- W2044101547 cites W2128717573 @default.
- W2044101547 cites W2130112708 @default.
- W2044101547 cites W2131470746 @default.
- W2044101547 cites W2142454930 @default.
- W2044101547 cites W2155902778 @default.
- W2044101547 cites W2160797407 @default.
- W2044101547 cites W2162395290 @default.
- W2044101547 cites W2315346240 @default.
- W2044101547 cites W2421826242 @default.
- W2044101547 cites W4243218069 @default.
- W2044101547 cites W4251014585 @default.
- W2044101547 doi "https://doi.org/10.1016/j.biopsych.2008.08.031" @default.
- W2044101547 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18973876" @default.
- W2044101547 hasPublicationYear "2008" @default.
- W2044101547 type Work @default.
- W2044101547 sameAs 2044101547 @default.
- W2044101547 citedByCount "45" @default.
- W2044101547 countsByYear W20441015472012 @default.
- W2044101547 countsByYear W20441015472013 @default.
- W2044101547 countsByYear W20441015472014 @default.
- W2044101547 countsByYear W20441015472015 @default.
- W2044101547 countsByYear W20441015472017 @default.