Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044103334> ?p ?o ?g. }
- W2044103334 endingPage "344" @default.
- W2044103334 startingPage "337" @default.
- W2044103334 abstract "In order to determine whether newly born cells in the dentate gyrus of the adult rat express the neuronal marker, neuron-specific enolase, or the glial marker, glial fibrillary acidic protein, we performed combined immunohistochemistry and autoradiography on brains from adult rats perfused at various times ranging from 1 h to four weeks following [3H]thymidine administration. Light-microscopic examination revealed a negligible number of [3H]thymidine-labeled cells showing neuron-specific enolase immunoreactivity during mitosis. However, by two weeks after [3H]thymidine administration, a significant increase in the density of [3H]thymidine-labeled neuron-specific enolase-immunoreactive cells was detected. Three weeks following [3H]thymidine injection the majority of [3H]thymidine-labeled cells (> 70%) were immunoreactive for the neuronal marker. At the four-week time-point, [3H]thymidine-labeled neuronspecific enolase-immunoreactive cells were indistinguishable from neighboring granule cells. In contrast, glial fibrillary acidic protein immunoreactivity was observed in a small but significant number of [3H]thymidine cells at the 1-h time-point and the proportion of labeled cells that were immunoreactive for this cell marker did not increase with time. [3H]Thymidine-labeled cells that were immunoreactive for glial fibrillary acidic protein typically showed morphologic characteristics of radial glia at all time-points. At the 1-h time-point, the majority of [3H]thymidine-labeled cells were observed in the hilus (> 60%) with the remainder being located in the granule cell layer. However, with a four-week survival-time most [3H]thymidine-labeled cells (> 85%) were located in the granule cell layer. The majority of newly born cells in the adult dentate gyrus differentiate into neurons. Some of these cells are born locally in the granule cell layer while others arise from the hilus and migrate to the granule cell layer. The presence of [3H]thymidine-labeled presumptive radial glia observed in the adult dentate gyrus supports the contention that many of the newly born neurons migrate. These results set the stage for future studies aimed at determining the factors that regulate these processes." @default.
- W2044103334 created "2016-06-24" @default.
- W2044103334 creator A5011488411 @default.
- W2044103334 creator A5017067300 @default.
- W2044103334 creator A5035103174 @default.
- W2044103334 creator A5062838866 @default.
- W2044103334 date "1993-09-01" @default.
- W2044103334 modified "2023-10-16" @default.
- W2044103334 title "Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat" @default.
- W2044103334 cites W1625103160 @default.
- W2044103334 cites W1772265277 @default.
- W2044103334 cites W1968770991 @default.
- W2044103334 cites W1979612418 @default.
- W2044103334 cites W1980499453 @default.
- W2044103334 cites W1983837059 @default.
- W2044103334 cites W2004230058 @default.
- W2044103334 cites W2006624547 @default.
- W2044103334 cites W2018048839 @default.
- W2044103334 cites W2024490431 @default.
- W2044103334 cites W2025399675 @default.
- W2044103334 cites W2043797153 @default.
- W2044103334 cites W2050572104 @default.
- W2044103334 cites W2053965650 @default.
- W2044103334 cites W2057147504 @default.
- W2044103334 cites W2059471650 @default.
- W2044103334 cites W2072673889 @default.
- W2044103334 cites W2077110494 @default.
- W2044103334 cites W2086066275 @default.
- W2044103334 cites W2091543295 @default.
- W2044103334 cites W2094885349 @default.
- W2044103334 cites W2100273026 @default.
- W2044103334 cites W2104073051 @default.
- W2044103334 cites W2107244153 @default.
- W2044103334 cites W2145400974 @default.
- W2044103334 doi "https://doi.org/10.1016/0306-4522(93)90335-d" @default.
- W2044103334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8247264" @default.
- W2044103334 hasPublicationYear "1993" @default.
- W2044103334 type Work @default.
- W2044103334 sameAs 2044103334 @default.
- W2044103334 citedByCount "1134" @default.
- W2044103334 countsByYear W20441033342012 @default.
- W2044103334 countsByYear W20441033342013 @default.
- W2044103334 countsByYear W20441033342014 @default.
- W2044103334 countsByYear W20441033342015 @default.
- W2044103334 countsByYear W20441033342016 @default.
- W2044103334 countsByYear W20441033342017 @default.
- W2044103334 countsByYear W20441033342018 @default.
- W2044103334 countsByYear W20441033342019 @default.
- W2044103334 countsByYear W20441033342020 @default.
- W2044103334 countsByYear W20441033342021 @default.
- W2044103334 countsByYear W20441033342022 @default.
- W2044103334 countsByYear W20441033342023 @default.
- W2044103334 crossrefType "journal-article" @default.
- W2044103334 hasAuthorship W2044103334A5011488411 @default.
- W2044103334 hasAuthorship W2044103334A5017067300 @default.
- W2044103334 hasAuthorship W2044103334A5035103174 @default.
- W2044103334 hasAuthorship W2044103334A5062838866 @default.
- W2044103334 hasConcept C134018914 @default.
- W2044103334 hasConcept C142724271 @default.
- W2044103334 hasConcept C151730666 @default.
- W2044103334 hasConcept C153911025 @default.
- W2044103334 hasConcept C169760540 @default.
- W2044103334 hasConcept C188618488 @default.
- W2044103334 hasConcept C202751555 @default.
- W2044103334 hasConcept C203014093 @default.
- W2044103334 hasConcept C204232928 @default.
- W2044103334 hasConcept C2776464000 @default.
- W2044103334 hasConcept C2777108182 @default.
- W2044103334 hasConcept C2777542381 @default.
- W2044103334 hasConcept C2778794669 @default.
- W2044103334 hasConcept C2778888523 @default.
- W2044103334 hasConcept C2780495277 @default.
- W2044103334 hasConcept C2780884517 @default.
- W2044103334 hasConcept C35866371 @default.
- W2044103334 hasConcept C49760210 @default.
- W2044103334 hasConcept C529278444 @default.
- W2044103334 hasConcept C55493867 @default.
- W2044103334 hasConcept C71924100 @default.
- W2044103334 hasConcept C86803240 @default.
- W2044103334 hasConceptScore W2044103334C134018914 @default.
- W2044103334 hasConceptScore W2044103334C142724271 @default.
- W2044103334 hasConceptScore W2044103334C151730666 @default.
- W2044103334 hasConceptScore W2044103334C153911025 @default.
- W2044103334 hasConceptScore W2044103334C169760540 @default.
- W2044103334 hasConceptScore W2044103334C188618488 @default.
- W2044103334 hasConceptScore W2044103334C202751555 @default.
- W2044103334 hasConceptScore W2044103334C203014093 @default.
- W2044103334 hasConceptScore W2044103334C204232928 @default.
- W2044103334 hasConceptScore W2044103334C2776464000 @default.
- W2044103334 hasConceptScore W2044103334C2777108182 @default.
- W2044103334 hasConceptScore W2044103334C2777542381 @default.
- W2044103334 hasConceptScore W2044103334C2778794669 @default.
- W2044103334 hasConceptScore W2044103334C2778888523 @default.
- W2044103334 hasConceptScore W2044103334C2780495277 @default.
- W2044103334 hasConceptScore W2044103334C2780884517 @default.
- W2044103334 hasConceptScore W2044103334C35866371 @default.
- W2044103334 hasConceptScore W2044103334C49760210 @default.
- W2044103334 hasConceptScore W2044103334C529278444 @default.