FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044112363> ?p ?o ?g. }

• W2044112363 abstract "The KRAB domain of human Kox1, a member of the KRAB C2H2 zinc finger family, confers strong transcriptional repressor activities even to remote promoter positions. Here, HDAC inhibitors were used to demonstrate that histone deacetylation is not required for mediating transcriptional repression of KRAB zinc finger proteins. Two reporter systems with either stably integrated or transiently transfected templates, both under control of strong viral promoters, were analyzed. Under all circumstances, HDAC inhibition did not alter the repression potential of the KRAB domain. In case of the stably integrated luciferase reporter gene system, neither expression levels of the KRAB fusion protein nor complex formation with its putative co-repressor TIF1beta were significantly changed. Furthermore, the TIF1beta/KRAB complex was devoid of mSin3A and HDAC1. In the transient transfection system, the transcriptional repression induced by TIF1beta and HP1alpha was not diminished by HDAC inhibitors, whereas the repressory activity of TIF1alpha was significantly affected. Thus, KRAB, TIF1beta and HP1alpha are likely to be functionally linked. In conclusion, HDAC activity is not essential for the strong transcriptional repressor activity mediated by the KRAB domain of Kox1 in particular and, presumably, by KRAB domains in general. This feature might be helpful in identifying and characterizing target genes under the control of" @default.
• W2044112363 created "2016-06-24" @default.
• W2044112363 creator A5041673166 @default.
• W2044112363 creator A5060233539 @default.
• W2044112363 creator A5061531129 @default.
• W2044112363 date "2001-01-27" @default.
• W2044112363 modified "2023-09-27" @default.
• W2044112363 title "Transcriptional Repression Mediated by the KRAB Domain of the Human C2H2 Zinc Finger Protein Kox1/ZNF10 Does Not Require Histone Deacetylation" @default.
• W2044112363 cites W1487669901 @default.
• W2044112363 cites W1497342202 @default.
• W2044112363 cites W1511815964 @default.
• W2044112363 cites W1689569903 @default.
• W2044112363 cites W1964858195 @default.
• W2044112363 cites W1972766406 @default.
• W2044112363 cites W1974314527 @default.
• W2044112363 cites W1978116091 @default.
• W2044112363 cites W1998006710 @default.
• W2044112363 cites W2001222172 @default.
• W2044112363 cites W2005035809 @default.
• W2044112363 cites W2006103371 @default.
• W2044112363 cites W2016818916 @default.
• W2044112363 cites W2034434851 @default.
• W2044112363 cites W2052808935 @default.
• W2044112363 cites W2054696920 @default.
• W2044112363 cites W2056793372 @default.
• W2044112363 cites W2066757189 @default.
• W2044112363 cites W2076446466 @default.
• W2044112363 cites W2076916406 @default.
• W2044112363 cites W2082579696 @default.
• W2044112363 cites W2085630342 @default.
• W2044112363 cites W2091309985 @default.
• W2044112363 cites W2093365231 @default.
• W2044112363 cites W2094049721 @default.
• W2044112363 cites W2095115211 @default.
• W2044112363 cites W2106109160 @default.
• W2044112363 cites W2106900373 @default.
• W2044112363 cites W2110576677 @default.
• W2044112363 cites W2121668326 @default.
• W2044112363 cites W2141130029 @default.
• W2044112363 cites W2142529970 @default.
• W2044112363 cites W2152326948 @default.
• W2044112363 cites W2156575042 @default.
• W2044112363 cites W2158074993 @default.
• W2044112363 cites W2158829419 @default.
• W2044112363 cites W2160402926 @default.
• W2044112363 cites W2161506097 @default.
• W2044112363 cites W2183407416 @default.
• W2044112363 doi "https://doi.org/10.1515/bc.2001.075" @default.
• W2044112363 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11405226" @default.
• W2044112363 hasPublicationYear "2001" @default.
• W2044112363 type Work @default.
• W2044112363 sameAs 2044112363 @default.
• W2044112363 citedByCount "23" @default.
• W2044112363 countsByYear W20441123632014 @default.
• W2044112363 countsByYear W20441123632019 @default.
• W2044112363 countsByYear W20441123632022 @default.
• W2044112363 countsByYear W20441123632023 @default.
• W2044112363 crossrefType "journal-article" @default.
• W2044112363 hasAuthorship W2044112363A5041673166 @default.
• W2044112363 hasAuthorship W2044112363A5060233539 @default.
• W2044112363 hasAuthorship W2044112363A5061531129 @default.
• W2044112363 hasConcept C101762097 @default.
• W2044112363 hasConcept C104317684 @default.
• W2044112363 hasConcept C122465829 @default.
• W2044112363 hasConcept C150194340 @default.
• W2044112363 hasConcept C153911025 @default.
• W2044112363 hasConcept C158448853 @default.
• W2044112363 hasConcept C186310378 @default.
• W2044112363 hasConcept C24284526 @default.
• W2044112363 hasConcept C27153228 @default.
• W2044112363 hasConcept C2778305200 @default.
• W2044112363 hasConcept C54355233 @default.
• W2044112363 hasConcept C62944979 @default.
• W2044112363 hasConcept C64927066 @default.
• W2044112363 hasConcept C85240754 @default.
• W2044112363 hasConcept C86339819 @default.
• W2044112363 hasConcept C86803240 @default.
• W2044112363 hasConcept C95444343 @default.
• W2044112363 hasConceptScore W2044112363C101762097 @default.
• W2044112363 hasConceptScore W2044112363C104317684 @default.
• W2044112363 hasConceptScore W2044112363C122465829 @default.
• W2044112363 hasConceptScore W2044112363C150194340 @default.
• W2044112363 hasConceptScore W2044112363C153911025 @default.
• W2044112363 hasConceptScore W2044112363C158448853 @default.
• W2044112363 hasConceptScore W2044112363C186310378 @default.
• W2044112363 hasConceptScore W2044112363C24284526 @default.
• W2044112363 hasConceptScore W2044112363C27153228 @default.
• W2044112363 hasConceptScore W2044112363C2778305200 @default.
• W2044112363 hasConceptScore W2044112363C54355233 @default.
• W2044112363 hasConceptScore W2044112363C62944979 @default.
• W2044112363 hasConceptScore W2044112363C64927066 @default.
• W2044112363 hasConceptScore W2044112363C85240754 @default.
• W2044112363 hasConceptScore W2044112363C86339819 @default.
• W2044112363 hasConceptScore W2044112363C86803240 @default.
• W2044112363 hasConceptScore W2044112363C95444343 @default.
• W2044112363 hasIssue "4" @default.
• W2044112363 hasLocation W20441123631 @default.
• W2044112363 hasLocation W20441123632 @default.
• W2044112363 hasOpenAccess W2044112363 @default.
• W2044112363 hasPrimaryLocation W20441123631 @default.

• next