Matches in SemOpenAlex for { <https://semopenalex.org/work/W204411292> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W204411292 endingPage "4" @default.
- W204411292 startingPage "142" @default.
- W204411292 abstract "Doxorubicin is a chemotherapeutic agent successfully used in the treatment of a wide range of cancers. However, with cumulative doses, doxorubicin also is known to have cardiotoxic effects, including cardiomyopathy and heart failure. Identification and quantification of myocardial cell damage has been a point of Controversy. We sought to identify these changes by measuring the levels of troponin I both 24 and 48 hr after the administration of doxorubicin as part of an antineoplastic treatment regimen. Thirty-eight patients scheduled to undergo treatment with doxorubicin were screened and approached for enrollment in the study. Thirty-one of them fulfilled all the inclusion criteria and also signed informed consent. All the patients enrolled in the study had blood drawn before the administration of doxorubicin and also 24 and 48 hr later. Electrocardiograms were performed prior to and 48 hr following the administration of chemotherapy. The dose of doxorubicin administered was calculated by the oncologist and ranged from 450 mg/m2-650 mg/m2 (mean 520 mg/m2). Only one patient was found to have en elevation of troponin levels both 24 and 48 hr (2.3 ng/mL and 2.1 ng/mL, respectively) after the administration of the drug. During that time, the patient denied any chest pain, shortness of breath or palpitations. Repeat ECG did not show any changes from the baseline. The remaining participants continued to maintain a troponin level of less than 0.3 ng/mL during the follow-up. In these patients, no electrocardiographic changes were noted in the follow-up ECG compared to the baseline; however, a slight drop in the ejection fraction without any impact on the clinical presentation was recorded. We concluded that the cTnl level does not change after the administration of doxorubicin, and thus cannot be used as a predictor of doxorubicin-induced cardiotoxicity." @default.
- W204411292 created "2016-06-24" @default.
- W204411292 creator A5049593902 @default.
- W204411292 creator A5058340300 @default.
- W204411292 creator A5059912984 @default.
- W204411292 creator A5070574365 @default.
- W204411292 creator A5076731823 @default.
- W204411292 creator A5079889215 @default.
- W204411292 creator A5085010737 @default.
- W204411292 date "2005-01-01" @default.
- W204411292 modified "2023-10-01" @default.
- W204411292 title "Troponin I as a marker of doxorubicin induced cardiotoxicity." @default.
- W204411292 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16416682" @default.
- W204411292 hasPublicationYear "2005" @default.
- W204411292 type Work @default.
- W204411292 sameAs 204411292 @default.
- W204411292 citedByCount "4" @default.
- W204411292 countsByYear W2044112922015 @default.
- W204411292 countsByYear W2044112922017 @default.
- W204411292 crossrefType "journal-article" @default.
- W204411292 hasAuthorship W204411292A5049593902 @default.
- W204411292 hasAuthorship W204411292A5058340300 @default.
- W204411292 hasAuthorship W204411292A5059912984 @default.
- W204411292 hasAuthorship W204411292A5070574365 @default.
- W204411292 hasAuthorship W204411292A5076731823 @default.
- W204411292 hasAuthorship W204411292A5079889215 @default.
- W204411292 hasAuthorship W204411292A5085010737 @default.
- W204411292 hasConcept C115725540 @default.
- W204411292 hasConcept C126322002 @default.
- W204411292 hasConcept C151032500 @default.
- W204411292 hasConcept C164705383 @default.
- W204411292 hasConcept C2776403943 @default.
- W204411292 hasConcept C2776694085 @default.
- W204411292 hasConcept C2778198053 @default.
- W204411292 hasConcept C2778233292 @default.
- W204411292 hasConcept C2778532138 @default.
- W204411292 hasConcept C2778704086 @default.
- W204411292 hasConcept C2778797674 @default.
- W204411292 hasConcept C2781303535 @default.
- W204411292 hasConcept C2781413609 @default.
- W204411292 hasConcept C36036425 @default.
- W204411292 hasConcept C42219234 @default.
- W204411292 hasConcept C500558357 @default.
- W204411292 hasConcept C71924100 @default.
- W204411292 hasConceptScore W204411292C115725540 @default.
- W204411292 hasConceptScore W204411292C126322002 @default.
- W204411292 hasConceptScore W204411292C151032500 @default.
- W204411292 hasConceptScore W204411292C164705383 @default.
- W204411292 hasConceptScore W204411292C2776403943 @default.
- W204411292 hasConceptScore W204411292C2776694085 @default.
- W204411292 hasConceptScore W204411292C2778198053 @default.
- W204411292 hasConceptScore W204411292C2778233292 @default.
- W204411292 hasConceptScore W204411292C2778532138 @default.
- W204411292 hasConceptScore W204411292C2778704086 @default.
- W204411292 hasConceptScore W204411292C2778797674 @default.
- W204411292 hasConceptScore W204411292C2781303535 @default.
- W204411292 hasConceptScore W204411292C2781413609 @default.
- W204411292 hasConceptScore W204411292C36036425 @default.
- W204411292 hasConceptScore W204411292C42219234 @default.
- W204411292 hasConceptScore W204411292C500558357 @default.
- W204411292 hasConceptScore W204411292C71924100 @default.
- W204411292 hasLocation W2044112921 @default.
- W204411292 hasOpenAccess W204411292 @default.
- W204411292 hasPrimaryLocation W2044112921 @default.
- W204411292 hasRelatedWork W1768777096 @default.
- W204411292 hasRelatedWork W1970064140 @default.
- W204411292 hasRelatedWork W2001868402 @default.
- W204411292 hasRelatedWork W204411292 @default.
- W204411292 hasRelatedWork W2076822831 @default.
- W204411292 hasRelatedWork W2085315051 @default.
- W204411292 hasRelatedWork W2168137676 @default.
- W204411292 hasRelatedWork W2342234320 @default.
- W204411292 hasRelatedWork W2909980364 @default.
- W204411292 hasRelatedWork W2265526624 @default.
- W204411292 hasVolume "48" @default.
- W204411292 isParatext "false" @default.
- W204411292 isRetracted "false" @default.
- W204411292 magId "204411292" @default.
- W204411292 workType "article" @default.