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• W2044133392 abstract "1 Chronic treatment of thyroidectomized rats with physiological doses of triiodothyronine leads to a significant increase in the incorporation of [3H]UTP into RNA by isolated rat liver mitochondria after the 4th day of treatment. 2 The increased activity of mitochondrial RNA polymerase is followed by a net increase in the RNA content of organelles which can be observed after the 5th day of chronic treatment. 3 Single injection of triiodothyronine at a dose of 250 μg/kg body wt also causes great stimulation of mitochondrial RNA synthesis which increases three-fold after 40 h. 4 At the same DNA/RNA ratio, RNA labelled in vitro with [3H]UTP from liver mitochondria of thyroidectomized animals hybridizes with mitochondrial DNA less efficiently than the newly synthesized RNA from liver mitochondria of animals treated for 10 days with 5 μg/100 g body wt of the hormone. 5 Hybridization-competition experiments with unlabelled RNA extracted from mitochondria of treated and untreated animals seem to suggest that a change in the transcription of mitochondrial DNA under the influence of the hormone occurs also in vivo." @default.
• W2044133392 created "2016-06-24" @default.
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• W2044133392 date "1972-10-01" @default.
• W2044133392 modified "2023-09-27" @default.
• W2044133392 title "Triiodothyronine Action on RNA Synthesis in Rat-Liver Mitochondria" @default.
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• W2044133392 doi "https://doi.org/10.1111/j.1432-1033.1972.tb02108.x" @default.
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