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- W2044133619 abstract "Blastocyst’s inability to hatch out of zona pellucida in time may lead to asynchronization of embryo and endometrium development causing implantation failure. So the aim of the study was to evaluate the efficiency of blastocyst collapsing and partial zona dissection performed before the fresh embryotransfer to ultimately facilitate embryo hatching. Retrospective comparative analysis. Totally we reviewed 243 fresh IVF-ICSI cycles involving embryotransfers of good quality blastocysts on 5th day of development. In first study group 2 intact blastocysts were transferred, while in other group one of the blastocysts was collapsed and ¼ of its zona outline was dissected before the embryotransfer procedure. Collapsing was performed with the help of laser (for blastocysts corresponding to Gardner’s grade 4) or mechanically (for blastocysts of grade 3). Collapsing not only contributed to trophectoderm and zona dissociation but also delivered space for zona fragment cutting. Partial dissection was performed with laser (Octax Laser Shot). Immediately after the formation of breach, embryos were transferred to patient’s uterus. Blastocyst collapsing and subsequent partial zona dissection of one of embryos transferred resulted in 14 % increase in pregnancy rate comparing to intact blastocyst transfer solely (p<0.01). Tabled 1ET of 2 intact blastocystsET of 1 intact and 1 collapsed blastocyst with zona pellucida dissectedNumber of IVF cycles125118Women age35.5±5.2 years35.7±3.8 yearsPregnancy rate53.8 %67.7 % Open table in a new tab Blastocyst collapsing and zona dissection significantly advance embryo hatching, save its energy that may be expended on complete release from zona pelucida and thereby enhance the possibility of embryo successful implantation. Competent use of the procedure promotes embryo implantation potential, synchronizes embryo development stage with endometrium ‘implantation window’ and as a result significantly increases the pregnancy rate in fresh blastocyst transfers." @default.
- W2044133619 created "2016-06-24" @default.
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- W2044133619 date "2014-09-01" @default.
- W2044133619 modified "2023-09-23" @default.
- W2044133619 title "Blastocyst collapsing and subsequent dissection of ¼ of zona pellucida before the embryotransfer significantly increase pregnancy rate in fresh cycles" @default.
- W2044133619 doi "https://doi.org/10.1016/j.fertnstert.2014.07.783" @default.
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