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• W2044135062 endingPage "49" @default.
• W2044135062 startingPage "42" @default.
• W2044135062 abstract "The heterologous production of the complex antibiotic erythromycin through Escherichia coli provides a unique challenge in metabolic engineering. In addition to introducing the 19 foreign genes needed for heterologous biosynthesis, E. coli metabolism must be engineered to provide the propionyl-CoA and (2S)-methylmalonyl-CoA substrates required to allow erythromycin formation. In this work, three different pathways to propionyl-CoA were compared in the context of supporting E. coli erythromycin biosynthesis. The comparison revealed that alternative citramalate and threonine metabolic pathways (both starting from exogenous glycerol) were capable of supporting final compound formation equal to a proven pathway reliant upon exogenous propionate. Furthermore, two pathways to (2S)-methylmalonyl-CoA were compared in the production of a novel benzyl-erythromycin analog. A pathway dependent upon exogenous methylmalonate improved selectivity and facilitated antibiotic assessment of this new analog." @default.
• W2044135062 created "2016-06-24" @default.
• W2044135062 creator A5044227760 @default.
• W2044135062 creator A5079480513 @default.
• W2044135062 date "2013-09-01" @default.
• W2044135062 modified "2023-10-18" @default.
• W2044135062 title "Metabolic and pathway engineering to influence native and altered erythromycin production through E. coli" @default.
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• W2044135062 doi "https://doi.org/10.1016/j.ymben.2013.05.005" @default.
• W2044135062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23747605" @default.
• W2044135062 hasPublicationYear "2013" @default.
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