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• W2044135398 abstract "A salting-out taste-masking system is a multiparticulate system consisting of a drug core, a salting-out layer containing salts and water-soluble polymers, and a water-penetration control layer containing water-insoluble materials. The system generates a long lag time for numbness masking, with subsequent immediate drug release for high bioavailability. In this study, sodium carbonate (Na2CO3) and hydroxypropylmethylcellulose (HPMC) were used as the salt and water-soluble polymer in the salting-out layer, respectively. The drug release rate from the formulation containing the HPMC layer was affected by the Na2CO3 concentrations in the media used in the drug dissolution tests. The HPMC layer suppressed drug release in a medium with a high Na2CO3 concentration, and subsequently increased the drug release rate in a medium with a low Na2CO3 concentration. Drug release from the system was suppressed while Na2CO3 remained in the formulations. Microscopic changes in HPMC in the salting-out layers correlated well with changes in the drug release rate. These results indicate that, in the salting-out taste-masking system, the drug release suppression and the immediate release are caused by insolubilization and dissolution of the water-soluble polymer respectively. These findings will allow for smarter formulation design." @default.
• W2044135398 created "2016-06-24" @default.
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• W2044135398 date "2008-10-01" @default.
• W2044135398 modified "2023-09-27" @default.
• W2044135398 title "Mechanism of controlled drug release from a salting-out taste-masking system" @default.
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• W2044135398 doi "https://doi.org/10.1016/j.jconrel.2008.07.009" @default.
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