FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044142184> ?p ?o ?g. }

• W2044142184 abstract "The genus Flavivirus currently consists of approximately 80 single-strand positive-sense RNA viruses. These replicate in a range of hosts including myriad vertebrate, insect, and tick species. As a consequence of this broad host range, the majority of flaviviruses can be propagated in most vertebrate and insect cell cultures. This ability to infect arthropods and vertebrates usually is essential for maintenance of these viruses in nature. But recently, there has been the discovery of a number of flaviviruses that infect mosquitoes but not vertebrates. It remains largely unknown why certain flaviviruses infect vertebrates and mosquitoes while others infect mosquitoes or vertebrates exclusively.Here, we initiated in vitro host range studies of Rabensburg virus (RABV), an intermediate between the mosquito-specific and horizontally transmitted flaviviruses, to provide information on the factor(s) that underlie the varying host range of flaviviruses. RABV is an intermediate between the mosquito-specific and horizontally transmitted flaviviruses because it does not infect mammalian or avian cell cultures, house sparrows, or chickens, but it does share genetic characteristics with the Japanese Encephalitis serogroup of flaviviruses.In vitro growth kinetic assays revealed the complete abrogation of RABV growth on Vero and E6 cells incubated at temperatures 35°C and higher, but surprisingly RABV infected, replicated efficiently, and displayed overt cytopathic effects (CPE) on Vero and E6 cell cultures incubated below 35°C. In contrast, RABV was fully viable, replicated efficiently, and displayed overt CPE on C6/36 cells incubated at 28°C or 37°C, thus implicating temperature as an important factor limiting the host range of RABV.These data are critical for further study to more fully identify the determinants that mediate the evolution of biological transmission among flaviviruses. It also will be useful for studies that look to provide a comprehensive molecular definition of flavivirus-host cell interactions. And it will provide a cadre of information to design wet lab experiments to investigate the genetic changes that facilitate host switching, which may lead to new vertebrate pathogens or transmission pathways." @default.
• W2044142184 created "2016-06-24" @default.
• W2044142184 creator A5012534121 @default.
• W2044142184 creator A5045481974 @default.
• W2044142184 date "2012-12-01" @default.
• W2044142184 modified "2023-10-17" @default.
• W2044142184 title "Replication of West Nile virus, Rabensburg lineage in mammalian cells is restricted by temperature" @default.
• W2044142184 cites W1866111900 @default.
• W2044142184 cites W193446248 @default.
• W2044142184 cites W1968071906 @default.
• W2044142184 cites W1969941684 @default.
• W2044142184 cites W1974942343 @default.
• W2044142184 cites W1984349715 @default.
• W2044142184 cites W1989521478 @default.
• W2044142184 cites W1998108299 @default.
• W2044142184 cites W1999927176 @default.
• W2044142184 cites W2003954336 @default.
• W2044142184 cites W2005578471 @default.
• W2044142184 cites W2039395021 @default.
• W2044142184 cites W2060253999 @default.
• W2044142184 cites W2083604454 @default.
• W2044142184 cites W2085405726 @default.
• W2044142184 cites W2103685216 @default.
• W2044142184 cites W2109711660 @default.
• W2044142184 cites W2110362074 @default.
• W2044142184 cites W2111501939 @default.
• W2044142184 cites W2111646120 @default.
• W2044142184 cites W2119351405 @default.
• W2044142184 cites W2124278697 @default.
• W2044142184 cites W2127864764 @default.
• W2044142184 cites W2128571608 @default.
• W2044142184 cites W2131390184 @default.
• W2044142184 cites W2137417976 @default.
• W2044142184 cites W2139433719 @default.
• W2044142184 cites W2140463382 @default.
• W2044142184 cites W2150891147 @default.
• W2044142184 cites W2154717655 @default.
• W2044142184 cites W2157475700 @default.
• W2044142184 cites W2158240087 @default.
• W2044142184 cites W2168869882 @default.
• W2044142184 cites W2170064307 @default.
• W2044142184 cites W2178124364 @default.
• W2044142184 cites W2187937073 @default.
• W2044142184 cites W4230043034 @default.
• W2044142184 cites W4235725807 @default.
• W2044142184 cites W4253772316 @default.
• W2044142184 cites W2049248780 @default.
• W2044142184 doi "https://doi.org/10.1186/1756-3305-5-293" @default.
• W2044142184 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3534007" @default.
• W2044142184 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23241081" @default.
• W2044142184 hasPublicationYear "2012" @default.
• W2044142184 type Work @default.
• W2044142184 sameAs 2044142184 @default.
• W2044142184 citedByCount "20" @default.
• W2044142184 countsByYear W20441421842014 @default.
• W2044142184 countsByYear W20441421842015 @default.
• W2044142184 countsByYear W20441421842016 @default.
• W2044142184 countsByYear W20441421842017 @default.
• W2044142184 countsByYear W20441421842019 @default.
• W2044142184 countsByYear W20441421842020 @default.
• W2044142184 countsByYear W20441421842021 @default.
• W2044142184 countsByYear W20441421842022 @default.
• W2044142184 countsByYear W20441421842023 @default.
• W2044142184 crossrefType "journal-article" @default.
• W2044142184 hasAuthorship W2044142184A5012534121 @default.
• W2044142184 hasAuthorship W2044142184A5045481974 @default.
• W2044142184 hasBestOaLocation W20441421841 @default.
• W2044142184 hasConcept C104317684 @default.
• W2044142184 hasConcept C126831891 @default.
• W2044142184 hasConcept C140704245 @default.
• W2044142184 hasConcept C159047783 @default.
• W2044142184 hasConcept C2522874641 @default.
• W2044142184 hasConcept C2776817793 @default.
• W2044142184 hasConcept C2780568436 @default.
• W2044142184 hasConcept C54355233 @default.
• W2044142184 hasConcept C86803240 @default.
• W2044142184 hasConcept C89138240 @default.
• W2044142184 hasConceptScore W2044142184C104317684 @default.
• W2044142184 hasConceptScore W2044142184C126831891 @default.
• W2044142184 hasConceptScore W2044142184C140704245 @default.
• W2044142184 hasConceptScore W2044142184C159047783 @default.
• W2044142184 hasConceptScore W2044142184C2522874641 @default.
• W2044142184 hasConceptScore W2044142184C2776817793 @default.
• W2044142184 hasConceptScore W2044142184C2780568436 @default.
• W2044142184 hasConceptScore W2044142184C54355233 @default.
• W2044142184 hasConceptScore W2044142184C86803240 @default.
• W2044142184 hasConceptScore W2044142184C89138240 @default.
• W2044142184 hasIssue "1" @default.
• W2044142184 hasLocation W20441421841 @default.
• W2044142184 hasLocation W20441421842 @default.
• W2044142184 hasLocation W20441421843 @default.
• W2044142184 hasLocation W20441421844 @default.
• W2044142184 hasOpenAccess W2044142184 @default.
• W2044142184 hasPrimaryLocation W20441421841 @default.
• W2044142184 hasRelatedWork W2008130004 @default.
• W2044142184 hasRelatedWork W2024701681 @default.
• W2044142184 hasRelatedWork W2049763445 @default.
• W2044142184 hasRelatedWork W2096211910 @default.
• W2044142184 hasRelatedWork W2098030187 @default.
• W2044142184 hasRelatedWork W2111868491 @default.

• next