FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044144944> ?p ?o ?g. }

• W2044144944 endingPage "211" @default.
• W2044144944 startingPage "205" @default.
• W2044144944 abstract "<h2>Abstract</h2> The filtration coefficient (<i>K</i>_f) in Starling's equation for fluid exchange was estimated in isolated reperfused canine lobes to evaluate the effect of ischemia-reperfusion injury on alveolar-capillary permeability quantitatively and to determine the inhibitory effects of a high dose of methylprednisolone (MPS) or dimethylthiourea (DMTU), a potent hydroxyl radical scavenger, on this injury. We reperfused isolated canine left lower lobes (LLLs) with blood at a constant flow after 3 hr of warm (38°C) or cold (4°C) ischemia and measured <i>K</i>_f after 1 hr of reperfusion. The mean value of <i>K</i>_f (±1 SD) in the cold ischemic lobes (COLD, <i>n</i> = 7), 0.13 ± 0.04 g·min⁻¹·cmH₂O⁻¹·100 g⁻¹, was not different from that in the control nonischemic lobes (CONT, <i>n</i> = 6), 0.10 ± 0.04 g·min⁻¹·cmH₂O⁻¹·100 g⁻¹. In contrast, the mean value of the <i>K</i>_f in the warm ischemic lobes (WARM, <i>n</i> = 7), 0.38 ± 0.17 g·min⁻¹·cmH₂O⁻¹·100 g⁻¹, was significantly (<i>P</i> < 0.001) higher than in CONT. MPS (30 mg/Kg) or DMTU (0.75 g/kg) administered before isolation of LLL and before reperfusion reduced the increase in <i>K</i>_f in warm ischemic lobes to 0.19 ± 0.09 and 0.19 ± 0.05 g·min⁻¹·cmH₂O⁻¹·100 g⁻¹, respectively (<i>P</i> < 0.005 WARM vs MPS, and <i>P</i> < 0.01 WARM vs DMTU). MPS and DMTU also attenuated the impairment of gas exchange. We conclude that (1) reperfusion after 3 hr of warm ischemia increases <i>K</i>_f but after cold ischemia does not, and (2) MPS and DMTU prevent the increase in <i>K</i>_f. Our data suggest that the ischemic-reperfusion lung injury may be due in part to the hydroxyl radical and some pharmacological agents can prevent the injury by attenuating increase in pulmonary microvascular permeability." @default.
• W2044144944 created "2016-06-24" @default.
• W2044144944 creator A5018269994 @default.
• W2044144944 creator A5019730719 @default.
• W2044144944 creator A5038239367 @default.
• W2044144944 creator A5061634903 @default.
• W2044144944 creator A5070138009 @default.
• W2044144944 creator A5081000734 @default.
• W2044144944 date "1991-03-01" @default.
• W2044144944 modified "2023-09-28" @default.
• W2044144944 title "Filtration coefficient in isolated preserved and reperfused canine lung" @default.
• W2044144944 cites W1783410164 @default.
• W2044144944 cites W1908006122 @default.
• W2044144944 cites W1965828553 @default.
• W2044144944 cites W2000675247 @default.
• W2044144944 cites W2018940868 @default.
• W2044144944 cites W2076622127 @default.
• W2044144944 cites W2095813074 @default.
• W2044144944 cites W2124428466 @default.
• W2044144944 cites W2135251295 @default.
• W2044144944 cites W2181117026 @default.
• W2044144944 cites W2190592547 @default.
• W2044144944 cites W2227507121 @default.
• W2044144944 cites W2245094202 @default.
• W2044144944 cites W2262424923 @default.
• W2044144944 cites W2264051238 @default.
• W2044144944 cites W2278001150 @default.
• W2044144944 cites W2333946890 @default.
• W2044144944 cites W2338865869 @default.
• W2044144944 cites W2395633570 @default.
• W2044144944 cites W2397629841 @default.
• W2044144944 cites W2406716942 @default.
• W2044144944 cites W2411346349 @default.
• W2044144944 cites W2413656280 @default.
• W2044144944 cites W2414611451 @default.
• W2044144944 cites W2418281073 @default.
• W2044144944 cites W2726410289 @default.
• W2044144944 cites W36705570 @default.
• W2044144944 doi "https://doi.org/10.1016/0022-4804(91)90179-p" @default.
• W2044144944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1900337" @default.
• W2044144944 hasPublicationYear "1991" @default.
• W2044144944 type Work @default.
• W2044144944 sameAs 2044144944 @default.
• W2044144944 citedByCount "14" @default.
• W2044144944 crossrefType "journal-article" @default.
• W2044144944 hasAuthorship W2044144944A5018269994 @default.
• W2044144944 hasAuthorship W2044144944A5019730719 @default.
• W2044144944 hasAuthorship W2044144944A5038239367 @default.
• W2044144944 hasAuthorship W2044144944A5061634903 @default.
• W2044144944 hasAuthorship W2044144944A5070138009 @default.
• W2044144944 hasAuthorship W2044144944A5081000734 @default.
• W2044144944 hasConcept C113196181 @default.
• W2044144944 hasConcept C126322002 @default.
• W2044144944 hasConcept C185592680 @default.
• W2044144944 hasConcept C43617362 @default.
• W2044144944 hasConcept C541997718 @default.
• W2044144944 hasConcept C71924100 @default.
• W2044144944 hasConceptScore W2044144944C113196181 @default.
• W2044144944 hasConceptScore W2044144944C126322002 @default.
• W2044144944 hasConceptScore W2044144944C185592680 @default.
• W2044144944 hasConceptScore W2044144944C43617362 @default.
• W2044144944 hasConceptScore W2044144944C541997718 @default.
• W2044144944 hasConceptScore W2044144944C71924100 @default.
• W2044144944 hasIssue "3" @default.
• W2044144944 hasLocation W20441449441 @default.
• W2044144944 hasLocation W20441449442 @default.
• W2044144944 hasOpenAccess W2044144944 @default.
• W2044144944 hasPrimaryLocation W20441449441 @default.
• W2044144944 hasRelatedWork W1531601525 @default.
• W2044144944 hasRelatedWork W1990781990 @default.
• W2044144944 hasRelatedWork W2314643286 @default.
• W2044144944 hasRelatedWork W2606768298 @default.
• W2044144944 hasRelatedWork W2606769243 @default.
• W2044144944 hasRelatedWork W2606837276 @default.
• W2044144944 hasRelatedWork W2748952813 @default.
• W2044144944 hasRelatedWork W2899084033 @default.
• W2044144944 hasRelatedWork W2948807893 @default.
• W2044144944 hasRelatedWork W2778153218 @default.
• W2044144944 hasVolume "50" @default.
• W2044144944 isParatext "false" @default.
• W2044144944 isRetracted "false" @default.
• W2044144944 magId "2044144944" @default.
• W2044144944 workType "article" @default.