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• W2044147407 abstract "Background:Albendazole (ABZ) is a benzimidazole carbamate compound currently in use for human medical practice against enterobiasis and soil-transmitted helminthiasis (STH); However, its spectrum of activity is broad and goes beyond these infections.Objective:This study compares the efficacy and safety of ABZ versus metronidazole (MTZ) in human giardiasis.Research design and methods:A randomized, double-blind, clinical trial was carried out at the Centre of Hygiene, Epidemiology and Microbiology in Matanzas City, Cuba. Adult patients with confirmed symptomatic G. duodenalis mono-infection were randomly assigned to receive either ABZ [400 mg daily (n = 75)] or MTZ [250 mg t.i.d. (n = 75)], both for 5 days. Follow-up fecal samples were obtained at 3, 5, 7 days after treatment end.Results:The efficacy was similar for both treatment groups: ABZ (82.6%) and MTZ (85.3%); p > 0.05. Side-effects including bitter taste, headache, vomiting and dizziness were significantly higher in the MTZ group. Abdominal pain was significantly higher in ABZ group.Conclusion:ABZ was found as effective as MTZ in the treatment of G. duodenalis infections in adult patients from Cuba and could be a useful drug in areas where co-infection with STH infections is common." @default.
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• W2044147407 date "2011-12-12" @default.
• W2044147407 modified "2023-09-28" @default.
• W2044147407 title "Albendazole versus metronidazole in the treatment of adult giardiasis: a randomized, double-blind, clinical trial" @default.
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• W2044147407 doi "https://doi.org/10.1185/03007995.2011.637915" @default.
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