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• W2044156043 endingPage "625" @default.
• W2044156043 startingPage "618" @default.
• W2044156043 abstract "Deviations from the physiological values of extracellular pH are monitored by multiple acid sensors. Acid-sensing ion channels are activated by moderate acidification, whereas transient receptor potential cation channels, notably TRPV1, are gated by severe acidosis. In contrast, ionotropic purinoceptor (P2X) ion channels, particularly P2X2, and two-pore domain background K+ channels, such as TASK, do not directly signal acidification but rather modulate cell membrane excitability in response to acidosis. These acid sensors, which are expressed by afferent neurons, are most relevant to the regulation of acid secretion, foregut motility and mucosal protection, as well as to gastrointestinal disturbances associated with inflammation, ischaemia and stasis." @default.
• W2044156043 created "2016-06-24" @default.
• W2044156043 creator A5005473061 @default.
• W2044156043 date "2003-12-01" @default.
• W2044156043 modified "2023-10-15" @default.
• W2044156043 title "Acid-sensitive ion channels in gastrointestinal function" @default.
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• W2044156043 doi "https://doi.org/10.1016/j.coph.2003.06.008" @default.
• W2044156043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14644014" @default.
• W2044156043 hasPublicationYear "2003" @default.
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