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• W2044164721 endingPage "10428" @default.
• W2044164721 startingPage "10418" @default.
• W2044164721 abstract "ABSTRACT During untreated human immunodeficiency virus type 1 (HIV-1) infection, virus-specific CD8 + T cells partially control HIV replication in peripheral lymphoid tissues, but host mechanisms of HIV control in the central nervous system (CNS) are incompletely understood. We characterized HIV-specific CD8 + T cells in cerebrospinal fluid (CSF) and peripheral blood among seven HIV-positive antiretroviral therapy-naïve subjects. All had grossly normal brain magnetic resonance imaging and spectroscopy and normal neuropsychometric testing. Frequencies of epitope-specific CD8 + T cells by direct tetramer staining were on average 2.4-fold higher in CSF than in blood ( P = 0.0004), while HIV RNA concentrations were lower. Cells from CSF were readily expanded ex vivo and responded to a broader range of HIV-specific human leukocyte antigen class I restricted optimal peptides than did expanded cells from blood. HIV-specific CD8 + T cells, in contrast to total CD8 + T cells, in CSF and blood were at comparable maturation states, as assessed by CD45RO and CCR7 staining. The strong relationship between higher T-cell frequencies and lower levels of viral antigen in CSF could be the result of increased migration to and/or preferential expansion of HIV-specific T cells within the CNS. This suggests an important role for HIV-specific CD8 + T cells in control of intrathecal viral replication." @default.
• W2044164721 created "2016-06-24" @default.
• W2044164721 creator A5016780373 @default.
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• W2044164721 date "2008-11-01" @default.
• W2044164721 modified "2023-09-23" @default.
• W2044164721 title "Enhancement of Human Immunodeficiency Virus (HIV)-Specific CD8⁺T Cells in Cerebrospinal Fluid Compared to Those in Blood among Antiretroviral Therapy-Naïve HIV-Positive Subjects" @default.
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• W2044164721 doi "https://doi.org/10.1128/jvi.01190-08" @default.
• W2044164721 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2573184" @default.
• W2044164721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18715919" @default.
• W2044164721 hasPublicationYear "2008" @default.

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