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- W2044166417 abstract "Primary cultured rat hepatocytes were used to study the cytotoxicity of sodium valproate (VPA). Cytotoxicity was monitored by measurement of leakage of intracellular enzymes into the culture medium: lactate dehydrogenase (LDH), glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT). The effects of D,L-carnitine and albumin administration on the cytotoxicity were evaluated. LDH leakage rose with an increasing dose of VPA. Administrations of D,L-carnitine and albumin reduced VPA hepatotoxicity. Our data suggest that VPA-induced hepatotoxicity is dose-related and may be modulated by serum carnitine and albumin levels." @default.
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- W2044166417 date "1988-08-01" @default.
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- W2044166417 title "Evaluation of the Cytotoxicity of Sodium Valproate on Primary Cultured Rat Hepatocytes" @default.
- W2044166417 doi "https://doi.org/10.1055/s-2008-1052421" @default.
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