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- W2044169091 abstract "The effects of stress on food intake and on neural activity in the lateral hypothalamic area (LHA) were investigated. Significant reduction of daily food intake was observed after 2 hr immobilization. The reduction of body weight was also significant during experimental days. Duplicate injections of methysergide (5 mg/kg, IP) antagonized the immobilization-induced anorexia for 3 hr and injection of naloxone had no effect. Single neuron activity was recorded from a chronically implanted electrode. Activity of 80% of LHA neurons was significantly decreased by immobilization stress. Methysergide significantly attenuated the suppressive effect of immobilization. Further, direct effects of 5-HT on LHA neurons were examined in anesthetized rats. Of 43 LHA neurons tested, the activity of 35 was inhibited by electrophoretic application of 5-HT. These results suggest that immobilization-induced anorexia is mediated at least in part through serotonergic mechanisms in the LHA." @default.
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- W2044169091 date "1989-11-01" @default.
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- W2044169091 title "Stress-induced anorexia in rats mediated by serotonergic mechanisms in the hypothalamus" @default.
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- W2044169091 doi "https://doi.org/10.1016/0031-9384(89)90045-0" @default.
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