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- W2044175090 abstract "Once inhaled, nanoparticles (NP) deposit on the lung surface and have first contact with the epithelial lung lining fluid (ELF) rich in proteins, which may bind to NP.In this study, we investigate the parameters that influence the binding between NP and proteins.We used the proteins albumin, transferrin (TF), and apolipoprotein A-1 (all known as proteins from ELF) and different NP (polystyrene NP with negative, positive, and neutral surface coatings, Printex G and Printex 90) as models.In all cases, a linear correlation of the added NP amount and the amount of bound proteins was found and was described quantitatively by binding indices. Bovine serum albumin (BSA), TF, and apo A-1 were bound to the largest extent to hydrophobic NP, which shows the extraordinary importance of the NP's surface properties.The binding index indicates the relevance of primary particle size and surface properties, including hydrophobicity.Size and surface modifications of NP determine their protein binding. Our results suggest that the formation of conjugates of BSA, TF, and Apo A-1 with NP may play an important role in their translocation across the air-blood-barrier and subsequent biokinetics." @default.
- W2044175090 created "2016-06-24" @default.
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- W2044175090 date "2011-06-20" @default.
- W2044175090 modified "2023-09-27" @default.
- W2044175090 title "Binding of polystyrene and carbon black nanoparticles to blood serum proteins" @default.
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- W2044175090 doi "https://doi.org/10.3109/08958378.2011.583944" @default.
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