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- W2044175529 abstract "5-Fluorouracil (FU) decreased the growth rate of Bacillus cereus, produced inhibition of synthesis of rRNA and ribosomes, and altered the physical properties of ribosomes. These effects were dependent on FU concentration and independent of retarded growth. The quantity of 23S RNA in the FU-treated cells was diminished to a greater extent than was that of 16S RNA, apparently because of ribonuclease degradation. Most of the RNA synthesized in the presence of FU was in the soluble fraction, and [14C] FU was selectively concentrated in this fraction. Ribosomes containing FU possessed a slightly lower thermal denaturation temperature. The 50S and 30S materials containing FU were unstable in 0.1 mM Mg2+. The ratio of RNA to protein synthesis was decreased in the 70S ribosomal fraction and increased in the soluble fraction of cells inhibited by FU." @default.
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- W2044175529 date "1971-08-01" @default.
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- W2044175529 title "Effects of fluorouracil on RNA synthesis in Bacillus cereus" @default.
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- W2044175529 doi "https://doi.org/10.1016/0006-2952(71)90397-2" @default.
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