FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044176507> ?p ?o ?g. }

• W2044176507 endingPage "3157" @default.
• W2044176507 startingPage "3150" @default.
• W2044176507 abstract "The effects of the channel-forming peptide gramicidin D (gD) on the conductance and electroporation thresholds of planar bilayer lipid membranes, made of the synthetic lipid 1-palmitoyl 2-oleoyl phosphatidylcholine (POPC), was studied. High-amplitude (∼200–900 mV) rectangular voltage pulses of 15 ms duration were used to perturb the bilayers and monitor the transmembrane conductance. Electroporation voltage thresholds were found, and conductance was recorded before and after electroporation. Gramicidin was added to the system in peptide/lipid ratios of 1:10,000, 1:500, and 1:15. The addition of gD in a ratio of 1:10,000 had no effect on electroporation, but ratios of 1:500 and 1:15 significantly increased the thresholds by 16% (p < 0.0001) and 40% (p < 0.0001), respectively. Membrane conductance before electroporation was measurable only after the addition of gD and increased monotonically as the peptide/lipid ratio increased. The effect of gD on the membrane area expansivity modulus (K) was tested using giant unilamellar vesicles (GUVs). When gD was incorporated into the vesicles in a 1:15 ratio, K increased by 110%, consistent with the increase in thresholds predicted by an electromechanical model. These findings suggest that the presence of membrane proteins may affect the electroporation of lipid bilayers by changing their mechanical properties." @default.
• W2044176507 created "2016-06-24" @default.
• W2044176507 creator A5000139869 @default.
• W2044176507 creator A5038323122 @default.
• W2044176507 creator A5078106020 @default.
• W2044176507 creator A5090717680 @default.
• W2044176507 date "1999-06-01" @default.
• W2044176507 modified "2023-09-23" @default.
• W2044176507 title "The Effects of Gramicidin on Electroporation of Lipid Bilayers" @default.
• W2044176507 cites W14946427 @default.
• W2044176507 cites W1624173240 @default.
• W2044176507 cites W1963722000 @default.
• W2044176507 cites W1964809614 @default.
• W2044176507 cites W1965970812 @default.
• W2044176507 cites W1968090330 @default.
• W2044176507 cites W1977557639 @default.
• W2044176507 cites W1979196854 @default.
• W2044176507 cites W1979262025 @default.
• W2044176507 cites W1980129676 @default.
• W2044176507 cites W1992450643 @default.
• W2044176507 cites W1992539915 @default.
• W2044176507 cites W1994215475 @default.
• W2044176507 cites W1996789620 @default.
• W2044176507 cites W1999383818 @default.
• W2044176507 cites W2000872543 @default.
• W2044176507 cites W2009069785 @default.
• W2044176507 cites W2013361763 @default.
• W2044176507 cites W2014184411 @default.
• W2044176507 cites W2032960272 @default.
• W2044176507 cites W2044485270 @default.
• W2044176507 cites W2046436993 @default.
• W2044176507 cites W2067970128 @default.
• W2044176507 cites W2069380507 @default.
• W2044176507 cites W2069948754 @default.
• W2044176507 cites W2080015784 @default.
• W2044176507 cites W2082781273 @default.
• W2044176507 cites W2117875609 @default.
• W2044176507 cites W2122698013 @default.
• W2044176507 cites W2159283890 @default.
• W2044176507 cites W2164027699 @default.
• W2044176507 cites W2237164154 @default.
• W2044176507 cites W2330442656 @default.
• W2044176507 cites W2987483052 @default.
• W2044176507 cites W87930704 @default.
• W2044176507 doi "https://doi.org/10.1016/s0006-3495(99)77466-7" @default.
• W2044176507 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1300283" @default.
• W2044176507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10354439" @default.
• W2044176507 hasPublicationYear "1999" @default.
• W2044176507 type Work @default.
• W2044176507 sameAs 2044176507 @default.
• W2044176507 citedByCount "26" @default.
• W2044176507 countsByYear W20441765072012 @default.
• W2044176507 countsByYear W20441765072013 @default.
• W2044176507 countsByYear W20441765072014 @default.
• W2044176507 countsByYear W20441765072015 @default.
• W2044176507 countsByYear W20441765072016 @default.
• W2044176507 countsByYear W20441765072017 @default.
• W2044176507 countsByYear W20441765072020 @default.
• W2044176507 crossrefType "journal-article" @default.
• W2044176507 hasAuthorship W2044176507A5000139869 @default.
• W2044176507 hasAuthorship W2044176507A5038323122 @default.
• W2044176507 hasAuthorship W2044176507A5078106020 @default.
• W2044176507 hasAuthorship W2044176507A5090717680 @default.
• W2044176507 hasBestOaLocation W20441765071 @default.
• W2044176507 hasConcept C104317684 @default.
• W2044176507 hasConcept C113196181 @default.
• W2044176507 hasConcept C114614502 @default.
• W2044176507 hasConcept C121932024 @default.
• W2044176507 hasConcept C12554922 @default.
• W2044176507 hasConcept C130316041 @default.
• W2044176507 hasConcept C181911157 @default.
• W2044176507 hasConcept C185592680 @default.
• W2044176507 hasConcept C186852380 @default.
• W2044176507 hasConcept C194544171 @default.
• W2044176507 hasConcept C2776989580 @default.
• W2044176507 hasConcept C2779281246 @default.
• W2044176507 hasConcept C2779650302 @default.
• W2044176507 hasConcept C2780943371 @default.
• W2044176507 hasConcept C33923547 @default.
• W2044176507 hasConcept C39944091 @default.
• W2044176507 hasConcept C41625074 @default.
• W2044176507 hasConcept C43617362 @default.
• W2044176507 hasConcept C55493867 @default.
• W2044176507 hasConcept C79879829 @default.
• W2044176507 hasConcept C86803240 @default.
• W2044176507 hasConceptScore W2044176507C104317684 @default.
• W2044176507 hasConceptScore W2044176507C113196181 @default.
• W2044176507 hasConceptScore W2044176507C114614502 @default.
• W2044176507 hasConceptScore W2044176507C121932024 @default.
• W2044176507 hasConceptScore W2044176507C12554922 @default.
• W2044176507 hasConceptScore W2044176507C130316041 @default.
• W2044176507 hasConceptScore W2044176507C181911157 @default.
• W2044176507 hasConceptScore W2044176507C185592680 @default.
• W2044176507 hasConceptScore W2044176507C186852380 @default.
• W2044176507 hasConceptScore W2044176507C194544171 @default.
• W2044176507 hasConceptScore W2044176507C2776989580 @default.
• W2044176507 hasConceptScore W2044176507C2779281246 @default.
• W2044176507 hasConceptScore W2044176507C2779650302 @default.

• next