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- W2044177675 abstract "The main objective of this paper is to review the potential diagnostic roles of exhaled nitric oxide (NO) in evaluating ischemia-reperfusion-induced lung injury associated with cardiac surgery. We shall start by elaborating on current clinical practice of cardiac surgery and to arrive at the conclusion that clinically important ischemia-reperfusion injury is a common scenario of many forms of these surgical procedures. We shall conclude this part by establishing the clinical need for biomarkers of inflammation in cardiothoracic surgery and by proposing that exhaled NO could be an important new addition to our anaesthetic monitoring repertoire based on our expertise with exhaled breath monitoring. We shall then take a closer look at mechanisms of ischemia-reperfusion injury and will propose the role of reactive oxygen and nitrogen species as mediators and biomarkers of acute lung injury. This analysis will provide a good opportunity to highlight major potential mechanisms of altered NO production and bioactivity of NO. We shall conclude that multiple relevant mechanisms may either lead to increased production of NO or enhance consumption of NO, leaving us with the paradigm that NO maybe used either as a positive or negative biomarker of inflammation. In order to explore this dilemma further, we will investigate the predominant effect of oxidative stress on NO bioactivity in cell culture models of ischemia-reperfusion injury. We will then turn to animal models of ischemia-reperfusion injury to elucidate the ultimate effects of this condition on lung NO production and concentrations of NO in the lung. Finally, we shall complete this journey by highlighting the human relevance of these observations by reviewing our own experience at Harefield Hospital, UK, and that of others, regarding exhaled NO in ischemia-reperfusion injury associated with cardiac surgery and lung transplantation." @default.
- W2044177675 created "2016-06-24" @default.
- W2044177675 creator A5049558077 @default.
- W2044177675 date "2005-12-01" @default.
- W2044177675 modified "2023-09-25" @default.
- W2044177675 title "The biology of exhaled nitric oxide (NO) in ischemia–reperfusion-induced lung injury: A tale of dynamism of NO production and consumption" @default.
- W2044177675 cites W120870122 @default.
- W2044177675 cites W1588777446 @default.
- W2044177675 cites W182126834 @default.
- W2044177675 cites W1899229346 @default.
- W2044177675 cites W1963753720 @default.
- W2044177675 cites W1965290067 @default.
- W2044177675 cites W1965693998 @default.
- W2044177675 cites W1965710093 @default.
- W2044177675 cites W1966728362 @default.
- W2044177675 cites W1966856205 @default.
- W2044177675 cites W1970245325 @default.
- W2044177675 cites W1971106335 @default.
- W2044177675 cites W1971153591 @default.
- W2044177675 cites W1972933720 @default.
- W2044177675 cites W1975503270 @default.
- W2044177675 cites W1978180398 @default.
- W2044177675 cites W1978902390 @default.
- W2044177675 cites W1979780797 @default.
- W2044177675 cites W1983146632 @default.
- W2044177675 cites W1983503298 @default.
- W2044177675 cites W1987256030 @default.
- W2044177675 cites W1988447687 @default.
- W2044177675 cites W1990656949 @default.
- W2044177675 cites W1993093207 @default.
- W2044177675 cites W1997030028 @default.
- W2044177675 cites W1999620478 @default.
- W2044177675 cites W2010359959 @default.
- W2044177675 cites W2012447588 @default.
- W2044177675 cites W2019056275 @default.
- W2044177675 cites W2019639614 @default.
- W2044177675 cites W2026617015 @default.
- W2044177675 cites W2028259055 @default.
- W2044177675 cites W2028838492 @default.
- W2044177675 cites W2031344267 @default.
- W2044177675 cites W2031836453 @default.
- W2044177675 cites W2034727322 @default.
- W2044177675 cites W2040515842 @default.
- W2044177675 cites W2041283753 @default.
- W2044177675 cites W2042611824 @default.
- W2044177675 cites W2042745519 @default.
- W2044177675 cites W2044703698 @default.
- W2044177675 cites W2044848723 @default.
- W2044177675 cites W2047358184 @default.
- W2044177675 cites W2049406319 @default.
- W2044177675 cites W2050054603 @default.
- W2044177675 cites W2051938970 @default.
- W2044177675 cites W2052030086 @default.
- W2044177675 cites W2053835713 @default.
- W2044177675 cites W2057792332 @default.
- W2044177675 cites W2058137293 @default.
- W2044177675 cites W2064071172 @default.
- W2044177675 cites W2065443731 @default.
- W2044177675 cites W2067678869 @default.
- W2044177675 cites W2073336247 @default.
- W2044177675 cites W2077172346 @default.
- W2044177675 cites W2081522480 @default.
- W2044177675 cites W2083461507 @default.
- W2044177675 cites W2083942811 @default.
- W2044177675 cites W2088082611 @default.
- W2044177675 cites W2090669872 @default.
- W2044177675 cites W2099997928 @default.
- W2044177675 cites W2114374419 @default.
- W2044177675 cites W2124260795 @default.
- W2044177675 cites W2126856589 @default.
- W2044177675 cites W2127710249 @default.
- W2044177675 cites W2131017492 @default.
- W2044177675 cites W2134371457 @default.
- W2044177675 cites W2137331279 @default.
- W2044177675 cites W2139349531 @default.
- W2044177675 cites W2140952528 @default.
- W2044177675 cites W2144488162 @default.
- W2044177675 cites W2145121139 @default.
- W2044177675 cites W2145570729 @default.
- W2044177675 cites W2146102937 @default.
- W2044177675 cites W2147819976 @default.
- W2044177675 cites W2165972867 @default.
- W2044177675 cites W2168202085 @default.
- W2044177675 cites W2169140191 @default.
- W2044177675 cites W2182716931 @default.
- W2044177675 cites W2413376601 @default.
- W2044177675 cites W4211171942 @default.
- W2044177675 cites W4240800534 @default.
- W2044177675 cites W4245072744 @default.
- W2044177675 cites W4248031230 @default.
- W2044177675 doi "https://doi.org/10.1016/j.vph.2005.08.011" @default.
- W2044177675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16290246" @default.
- W2044177675 hasPublicationYear "2005" @default.
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