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- W2044177894 abstract "Salvage radiation therapy (SRT) for patients with a rising PSA after prostatectomy has been demonstrated to improve biochemical control and cause-specific survival. Despite an absence of published randomized controlled trials for patients receiving SRT, consensus papers have been published to help guide clinical management. While these recommendations are useful, they do not address many practical decisions. Thus, we sought to survey radiation oncologists (ROs) around the world who offer SRT for patients with post-prostatectomy biochemical failure to better understand current practice trends. Active ROs were identified using the American Society of Radiation Oncology member directory, and solicited via e-mail to participate in a web-based questionnaire using SurveyMonkey. The survey consisted of 21 questions regarding clinical indications, workup, treatment planning technique, and use of adjuvant androgen deprivation therapy (ADT) during SRT. Preferences for utilization of elective nodal irradiation were explored. There were 999 ROs who completed the survey after acknowledging they currently treat prostate cancer. Ninety nine percent stated they offer SRT for biochemical relapse. Eighty-five percent choose to initiate SRT at a PSA ≤0.6. Bone scan and CT of the pelvis remain the most common tools for ruling out metastatic disease prior to local therapy. IMRT and 3-D planning for SRT have almost completely replaced 2-D planning, which was offered only 1.1% of the time. Almost 90% will deliver a dose between 64.8 and 70.2 Gy. Seventy percent will consider electively treating the pelvic lymph nodes, a decision driven primarily by Gleason score and seminal vesicle involvement. More than half of ROs offer adjuvant ADT with SRT, for a period between 6 months to 2 years. There is world-wide agreement on general treatment decisions for managing patients undergoing SRT following prostatectomy. However, variability exists with many clinical issues. Despite a paucity of evidence demonstrating improved clinical outcomes, the majority of respondents utilize elective nodal irradiation and/or ADT. More research is needed to support practical decisions which remain unaddressed in current published guidelines. Enrollment of patients with post-prostatectomy biochemical relapse onto RTOG 0534 is encouraged to help better identify the clinical utility of elective lymph node irradiation and/or ADT." @default.
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- W2044177894 date "2011-10-01" @default.
- W2044177894 modified "2023-09-25" @default.
- W2044177894 title "Current Practice Trends for Managing Post-Prostatectomy Biochemical Relapse with Salvage Radiotherapy: Results of a World-Wide Survey" @default.
- W2044177894 doi "https://doi.org/10.1016/j.ijrobp.2011.06.657" @default.
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