Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044178718> ?p ?o ?g. }
- W2044178718 endingPage "158" @default.
- W2044178718 startingPage "147" @default.
- W2044178718 abstract "Metazoans tolerate commensal-gut microbiota by suppressing immune activation while maintaining the ability to launch rapid and balanced immune reactions to pathogenic bacteria. Little is known about the mechanisms underlying the establishment of this threshold. We report that a recently identified Drosophila immune regulator, which we call PGRP-LC-interacting inhibitor of Imd signaling (PIMS), is required to suppress the Imd innate immune signaling pathway in response to commensal bacteria. pims expression is Imd (immune deficiency) dependent, and its basal expression relies on the presence of commensal flora. In the absence of PIMS, resident bacteria trigger constitutive expression of antimicrobial peptide genes (AMPs). Moreover, pims mutants hyperactivate AMPs upon infection with Gram-negative bacteria. PIMS interacts with the peptidoglycan recognition protein (PGRP-LC), causing its depletion from the plasma membrane and shutdown of Imd signaling. Therefore, PIMS is required to establish immune tolerance to commensal bacteria and to maintain a balanced Imd response following exposure to bacterial infections." @default.
- W2044178718 created "2016-06-24" @default.
- W2044178718 creator A5001528401 @default.
- W2044178718 creator A5008098404 @default.
- W2044178718 creator A5020742210 @default.
- W2044178718 creator A5026910100 @default.
- W2044178718 creator A5030754341 @default.
- W2044178718 creator A5048150127 @default.
- W2044178718 creator A5065412863 @default.
- W2044178718 creator A5068148066 @default.
- W2044178718 creator A5068439122 @default.
- W2044178718 creator A5083235919 @default.
- W2044178718 date "2008-08-01" @default.
- W2044178718 modified "2023-10-15" @default.
- W2044178718 title "PIMS Modulates Immune Tolerance by Negatively Regulating Drosophila Innate Immune Signaling" @default.
- W2044178718 cites W146249449 @default.
- W2044178718 cites W1754711307 @default.
- W2044178718 cites W1941515972 @default.
- W2044178718 cites W1977454530 @default.
- W2044178718 cites W1980077364 @default.
- W2044178718 cites W1980914602 @default.
- W2044178718 cites W1982279452 @default.
- W2044178718 cites W1984133423 @default.
- W2044178718 cites W1993827187 @default.
- W2044178718 cites W1994557554 @default.
- W2044178718 cites W1994599007 @default.
- W2044178718 cites W1996858055 @default.
- W2044178718 cites W2002088088 @default.
- W2044178718 cites W2003156936 @default.
- W2044178718 cites W2004732995 @default.
- W2044178718 cites W2006768051 @default.
- W2044178718 cites W2012532513 @default.
- W2044178718 cites W2016143376 @default.
- W2044178718 cites W2016740042 @default.
- W2044178718 cites W2019703934 @default.
- W2044178718 cites W2023420554 @default.
- W2044178718 cites W2025114863 @default.
- W2044178718 cites W2025357023 @default.
- W2044178718 cites W2039895788 @default.
- W2044178718 cites W2040438060 @default.
- W2044178718 cites W2061708393 @default.
- W2044178718 cites W2064082040 @default.
- W2044178718 cites W2064647551 @default.
- W2044178718 cites W2074898833 @default.
- W2044178718 cites W2075724869 @default.
- W2044178718 cites W2077906612 @default.
- W2044178718 cites W2079639127 @default.
- W2044178718 cites W2090774689 @default.
- W2044178718 cites W2092960662 @default.
- W2044178718 cites W2093611483 @default.
- W2044178718 cites W2097042447 @default.
- W2044178718 cites W2099030642 @default.
- W2044178718 cites W2102549002 @default.
- W2044178718 cites W2110019438 @default.
- W2044178718 cites W2137019479 @default.
- W2044178718 cites W2144770467 @default.
- W2044178718 cites W2151563669 @default.
- W2044178718 cites W2153210121 @default.
- W2044178718 cites W2154210643 @default.
- W2044178718 cites W2165116042 @default.
- W2044178718 cites W2292249423 @default.
- W2044178718 cites W284442361 @default.
- W2044178718 cites W4242475063 @default.
- W2044178718 doi "https://doi.org/10.1016/j.chom.2008.07.004" @default.
- W2044178718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18692774" @default.
- W2044178718 hasPublicationYear "2008" @default.
- W2044178718 type Work @default.
- W2044178718 sameAs 2044178718 @default.
- W2044178718 citedByCount "205" @default.
- W2044178718 countsByYear W20441787182012 @default.
- W2044178718 countsByYear W20441787182013 @default.
- W2044178718 countsByYear W20441787182014 @default.
- W2044178718 countsByYear W20441787182015 @default.
- W2044178718 countsByYear W20441787182016 @default.
- W2044178718 countsByYear W20441787182017 @default.
- W2044178718 countsByYear W20441787182018 @default.
- W2044178718 countsByYear W20441787182019 @default.
- W2044178718 countsByYear W20441787182020 @default.
- W2044178718 countsByYear W20441787182021 @default.
- W2044178718 countsByYear W20441787182022 @default.
- W2044178718 countsByYear W20441787182023 @default.
- W2044178718 crossrefType "journal-article" @default.
- W2044178718 hasAuthorship W2044178718A5001528401 @default.
- W2044178718 hasAuthorship W2044178718A5008098404 @default.
- W2044178718 hasAuthorship W2044178718A5020742210 @default.
- W2044178718 hasAuthorship W2044178718A5026910100 @default.
- W2044178718 hasAuthorship W2044178718A5030754341 @default.
- W2044178718 hasAuthorship W2044178718A5048150127 @default.
- W2044178718 hasAuthorship W2044178718A5065412863 @default.
- W2044178718 hasAuthorship W2044178718A5068148066 @default.
- W2044178718 hasAuthorship W2044178718A5068439122 @default.
- W2044178718 hasAuthorship W2044178718A5083235919 @default.
- W2044178718 hasBestOaLocation W20441787181 @default.
- W2044178718 hasConcept C104317684 @default.
- W2044178718 hasConcept C136449434 @default.
- W2044178718 hasConcept C143065580 @default.
- W2044178718 hasConcept C203014093 @default.
- W2044178718 hasConcept C2776634448 @default.