FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044178731> ?p ?o ?g. }

• W2044178731 endingPage "375" @default.
• W2044178731 startingPage "365" @default.
• W2044178731 abstract "The motivational effects of nicotine-associated cues have been demonstrated in animal studies. However, it is unknown whether the effectiveness of nicotine cues in reinstating nicotine-seeking varies with the extent of prior nicotine self-administration. In addition, the issue of whether bupropion (an FDA-approved smoking cessation medication) interferes with the conditioned incentive of nicotine cues remains to be addressed. This study determined the relationship of cue-reinstated nicotine-seeking and the levels of prior self-administration and examined the effect of bupropion on cue-induced reinstatement of nicotine-seeking in comparison with that on self-administration. Male Sprague–Dawley rats were trained in daily 1-h sessions to intravenously self-administer nicotine at different doses (0, 0.015, 0.03, 0.06 mg/kg/infusion) and to associate an auditory/visual cue with each nicotine delivery. After extinction, three reinstatement tests at 15 day intervals were conducted with re-presentation of the cue without nicotine delivery. In separate groups of rats trained with 0.03 mg/kg/infusion nicotine, bupropion (0, 10, 20, 40 mg/kg) was intraperitoneally administered to different groups before the reinstatement and in a within-subject design before the self-administration tests. Cue-induced reinstatement of active lever responses was observed at all nicotine doses in the first reinstatement test, but at only the two highest doses during the second and third tests. The magnitude of reinstatement was positively correlated with level of prior responding for nicotine. Bupropion pretreatment decreased nicotine self-administration but enhanced cue-reinstated nicotine-seeking. These results demonstrate the positive correlation of cue-reinstated nicotine-seeking with prior responding for nicotine self-administration and the persistence of the cue effect after taking higher doses of nicotine. The results of pharmacological tests suggest that although it is able to help achieve smoking cessation, bupropion may have little clinical benefit for the prevention of relapse associated with exposure to environmental smoking cues." @default.
• W2044178731 created "2016-06-24" @default.
• W2044178731 creator A5013978633 @default.
• W2044178731 creator A5023888467 @default.
• W2044178731 creator A5025219266 @default.
• W2044178731 creator A5033981457 @default.
• W2044178731 creator A5085252579 @default.
• W2044178731 date "2007-10-12" @default.
• W2044178731 modified "2023-09-23" @default.
• W2044178731 title "Cue-induced reinstatement of nicotine-seeking behavior in rats: effect of bupropion, persistence over repeated tests, and its dependence on training dose" @default.
• W2044178731 cites W173345151 @default.
• W2044178731 cites W1964739293 @default.
• W2044178731 cites W1967566314 @default.
• W2044178731 cites W1971422825 @default.
• W2044178731 cites W1971669832 @default.
• W2044178731 cites W1972140272 @default.
• W2044178731 cites W1974132634 @default.
• W2044178731 cites W1976328383 @default.
• W2044178731 cites W1980215757 @default.
• W2044178731 cites W1984880664 @default.
• W2044178731 cites W1986146789 @default.
• W2044178731 cites W1986183173 @default.
• W2044178731 cites W1991978791 @default.
• W2044178731 cites W1992710392 @default.
• W2044178731 cites W1992865170 @default.
• W2044178731 cites W1993640976 @default.
• W2044178731 cites W1993787748 @default.
• W2044178731 cites W1993963628 @default.
• W2044178731 cites W1994470828 @default.
• W2044178731 cites W1996954387 @default.
• W2044178731 cites W1997119641 @default.
• W2044178731 cites W2000283387 @default.
• W2044178731 cites W2000519774 @default.
• W2044178731 cites W2004634810 @default.
• W2044178731 cites W2010632960 @default.
• W2044178731 cites W2018548583 @default.
• W2044178731 cites W2019530923 @default.
• W2044178731 cites W2023136242 @default.
• W2044178731 cites W2024819282 @default.
• W2044178731 cites W2026479980 @default.
• W2044178731 cites W2029181754 @default.
• W2044178731 cites W2031046387 @default.
• W2044178731 cites W2032389586 @default.
• W2044178731 cites W2033657283 @default.
• W2044178731 cites W2038809863 @default.
• W2044178731 cites W2040903782 @default.
• W2044178731 cites W2041139441 @default.
• W2044178731 cites W2044906090 @default.
• W2044178731 cites W2046936720 @default.
• W2044178731 cites W2049730020 @default.
• W2044178731 cites W2052323109 @default.
• W2044178731 cites W2052442783 @default.
• W2044178731 cites W2054053664 @default.
• W2044178731 cites W2054723045 @default.
• W2044178731 cites W2056579603 @default.
• W2044178731 cites W2056711311 @default.
• W2044178731 cites W2057281025 @default.
• W2044178731 cites W2059083245 @default.
• W2044178731 cites W2064155366 @default.
• W2044178731 cites W2070212982 @default.
• W2044178731 cites W2072459855 @default.
• W2044178731 cites W2074243312 @default.
• W2044178731 cites W2076934910 @default.
• W2044178731 cites W2081491792 @default.
• W2044178731 cites W2083739499 @default.
• W2044178731 cites W2087657646 @default.
• W2044178731 cites W2088216599 @default.
• W2044178731 cites W2088355418 @default.
• W2044178731 cites W2092736562 @default.
• W2044178731 cites W2103263170 @default.
• W2044178731 cites W2109413549 @default.
• W2044178731 cites W2117585358 @default.
• W2044178731 cites W2133374870 @default.
• W2044178731 cites W2140993436 @default.
• W2044178731 cites W2148758048 @default.
• W2044178731 cites W2153220298 @default.
• W2044178731 cites W2154598652 @default.
• W2044178731 cites W2160531011 @default.
• W2044178731 cites W2171592578 @default.
• W2044178731 cites W2312609348 @default.
• W2044178731 cites W2317321545 @default.
• W2044178731 cites W2323479632 @default.
• W2044178731 cites W4234118263 @default.
• W2044178731 cites W4243345735 @default.
• W2044178731 cites W4246056884 @default.
• W2044178731 cites W4248941125 @default.
• W2044178731 cites W4253650414 @default.
• W2044178731 cites W4253936103 @default.
• W2044178731 doi "https://doi.org/10.1007/s00213-007-0967-9" @default.
• W2044178731 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2812900" @default.
• W2044178731 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17932656" @default.
• W2044178731 hasPublicationYear "2007" @default.
• W2044178731 type Work @default.
• W2044178731 sameAs 2044178731 @default.
• W2044178731 citedByCount "75" @default.
• W2044178731 countsByYear W20441787312012 @default.
• W2044178731 countsByYear W20441787312013 @default.
• W2044178731 countsByYear W20441787312014 @default.

• next