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• W2044185280 endingPage "2024" @default.
• W2044185280 startingPage "2016" @default.
• W2044185280 abstract "The aim of this study was to test the hypotheses that retroviral gene transfer of SOX trio enhances the in vitro chondrogenic differentiation of ASCs, and that SOX trio-co-transduced ASCs in fibrin gel promote the healing of osteochondral defects, and arrest the progression of surgically-induced osteoarthritis in a rat model. ASCs isolated from inguinal fat in rats were transduced with SOX trio genes using retrovirus, and further cultured in vitro in pellets for 21 days, then analyzed for gene and protein expression of SOX trio and chondrogenic markers. SOX trio-co-transduced ASCs in fibrin gel were implanted on the osteochondral defect created in the patellar groove of the distal femur, and also injected into the knee joints of rats with surgically-induced osteoarthritis. Rats were sacrificed after 8 weeks, and analyzed grossly and microscopically. After 21 days, ASCs transduced with SOX-5, -6, or -9 had hundreds-fold greater gene expression of each gene compared with the control with the SOX protein expression matching gene expression. SOX trio-co-transduction significantly increased GAG contents as well as type II collagen gene and protein expression. ASCs co-transduced with SOX trio significantly promoted the in vivo cartilage healing in osteochondral defect model, and prevented the progression of degenerative changes in surgically-induced osteoarthritis." @default.
• W2044185280 created "2016-06-24" @default.
• W2044185280 creator A5035808348 @default.
• W2044185280 creator A5075161590 @default.
• W2044185280 date "2012-03-01" @default.
• W2044185280 modified "2023-10-17" @default.
• W2044185280 title "SOX trio-co-transduced adipose stem cells in fibrin gel to enhance cartilage repair and delay the progression of osteoarthritis in the rat" @default.
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• W2044185280 doi "https://doi.org/10.1016/j.biomaterials.2011.11.050" @default.
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• W2044185280 hasPublicationYear "2012" @default.
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