Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044186109> ?p ?o ?g. }
- W2044186109 endingPage "e270" @default.
- W2044186109 startingPage "e270" @default.
- W2044186109 abstract "Autism spectrum disorders (ASDs) are highly heritable, and six genome-wide association studies (GWASs) of ASDs have been published to date. In this study, we have integrated the findings from these GWASs with other genetic data to identify enriched genetic networks that are associated with ASDs. We conducted bioinformatics and systematic literature analyses of 200 top-ranked ASD candidate genes from five published GWASs. The sixth GWAS was used for replication and validation of our findings. Further corroborating evidence was obtained through rare genetic variant studies, that is, exome sequencing and copy number variation (CNV) studies, and/or other genetic evidence, including candidate gene association, microRNA and gene expression, gene function and genetic animal studies. We found three signaling networks regulating steroidogenesis, neurite outgrowth and (glutamatergic) synaptic function to be enriched in the data. Most genes from the five GWASs were also implicated--independent of gene size--in ASDs by at least one other line of genomic evidence. Importantly, A-kinase anchor proteins (AKAPs) functionally integrate signaling cascades within and between these networks. The three identified protein networks provide an important contribution to increasing our understanding of the molecular basis of ASDs. In addition, our results point towards the AKAPs as promising targets for developing novel ASD treatments." @default.
- W2044186109 created "2016-06-24" @default.
- W2044186109 creator A5005234660 @default.
- W2044186109 creator A5009149756 @default.
- W2044186109 creator A5032615209 @default.
- W2044186109 creator A5038874292 @default.
- W2044186109 creator A5085834116 @default.
- W2044186109 date "2013-06-11" @default.
- W2044186109 modified "2023-10-06" @default.
- W2044186109 title "AKAPs integrate genetic findings for autism spectrum disorders" @default.
- W2044186109 cites W1495797590 @default.
- W2044186109 cites W1496980490 @default.
- W2044186109 cites W1964444099 @default.
- W2044186109 cites W1968130118 @default.
- W2044186109 cites W1969135502 @default.
- W2044186109 cites W1970848271 @default.
- W2044186109 cites W1975216375 @default.
- W2044186109 cites W1976358763 @default.
- W2044186109 cites W1976905805 @default.
- W2044186109 cites W1977497843 @default.
- W2044186109 cites W1979250362 @default.
- W2044186109 cites W1982054620 @default.
- W2044186109 cites W1985466543 @default.
- W2044186109 cites W1987742805 @default.
- W2044186109 cites W1990023165 @default.
- W2044186109 cites W1991085184 @default.
- W2044186109 cites W1991160835 @default.
- W2044186109 cites W1993360322 @default.
- W2044186109 cites W1994016401 @default.
- W2044186109 cites W1995647101 @default.
- W2044186109 cites W2002904206 @default.
- W2044186109 cites W2012203722 @default.
- W2044186109 cites W2015213948 @default.
- W2044186109 cites W2016781419 @default.
- W2044186109 cites W2017867103 @default.
- W2044186109 cites W2019983262 @default.
- W2044186109 cites W2020917189 @default.
- W2044186109 cites W2020960495 @default.
- W2044186109 cites W2020963727 @default.
- W2044186109 cites W2024636649 @default.
- W2044186109 cites W2024663595 @default.
- W2044186109 cites W2027455260 @default.
- W2044186109 cites W2028060696 @default.
- W2044186109 cites W2035069442 @default.
- W2044186109 cites W2035496732 @default.
- W2044186109 cites W2037094026 @default.
- W2044186109 cites W2037302793 @default.
- W2044186109 cites W2040268226 @default.
- W2044186109 cites W2044852143 @default.
- W2044186109 cites W2055045760 @default.
- W2044186109 cites W2055849573 @default.
- W2044186109 cites W2061608089 @default.
- W2044186109 cites W2067513312 @default.
- W2044186109 cites W2069696742 @default.
- W2044186109 cites W2071731410 @default.
- W2044186109 cites W2073062083 @default.
- W2044186109 cites W2074236300 @default.
- W2044186109 cites W2078771459 @default.
- W2044186109 cites W2078797296 @default.
- W2044186109 cites W2080287250 @default.
- W2044186109 cites W2080528445 @default.
- W2044186109 cites W2085198610 @default.
- W2044186109 cites W2085331090 @default.
- W2044186109 cites W2087481719 @default.
- W2044186109 cites W2088982569 @default.
- W2044186109 cites W2090823243 @default.
- W2044186109 cites W2092630887 @default.
- W2044186109 cites W2092913927 @default.
- W2044186109 cites W2105575850 @default.
- W2044186109 cites W2108210377 @default.
- W2044186109 cites W2109403514 @default.
- W2044186109 cites W2109529720 @default.
- W2044186109 cites W2110374888 @default.
- W2044186109 cites W2112471545 @default.
- W2044186109 cites W2113381731 @default.
- W2044186109 cites W2116189373 @default.
- W2044186109 cites W2116964354 @default.
- W2044186109 cites W2117154339 @default.
- W2044186109 cites W2117949808 @default.
- W2044186109 cites W2118018788 @default.
- W2044186109 cites W2119907069 @default.
- W2044186109 cites W2122665832 @default.
- W2044186109 cites W2123739801 @default.
- W2044186109 cites W2127634492 @default.
- W2044186109 cites W2127753140 @default.
- W2044186109 cites W2128503836 @default.
- W2044186109 cites W2131104106 @default.
- W2044186109 cites W2131203011 @default.
- W2044186109 cites W2136091734 @default.
- W2044186109 cites W2137042012 @default.
- W2044186109 cites W2140443825 @default.
- W2044186109 cites W2142014244 @default.
- W2044186109 cites W2142076791 @default.
- W2044186109 cites W2143333975 @default.
- W2044186109 cites W2144457054 @default.
- W2044186109 cites W2144601878 @default.
- W2044186109 cites W2148000302 @default.
- W2044186109 cites W2148147994 @default.