Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044188057> ?p ?o ?g. }
- W2044188057 abstract "Primary bone tumors are rare, but their treatments have enjoyed considerable improvements in life expectancy because of chemotherapy. When combined with advances in surgery, patients can now expect lives and limbs to behave with greater longevity and normality. The challenge now is how to raise the plateau of survival, and that means finding a successful way to treat metastatic or unsalvageable local disease. It is clear that conventional chemotherapy has limitations and that the answer may lie in a better understanding of the intricate molecular workings of cancer and the pathways that lead to the latter’s growth, invasion, and dissemination. There have been great strides made in dissecting out the metastatic cascade with numerous important pathways and molecular switches identified. This has led to the introduction of a number of new drugs and molecules aimed at targeting the molecular vulnerabilities of cancer, allowing greater control of growth, invasion, and metastasis. Some of these have had a large impact on musculoskeletal malignancies. Future successes in treatment will require multimodal targeting of tumors whose signatures will be a composite of histologic and molecular markers that will pave the way for personalization of treatment strategies." @default.
- W2044188057 created "2016-06-24" @default.
- W2044188057 creator A5014346063 @default.
- W2044188057 date "2014-05-09" @default.
- W2044188057 modified "2023-10-17" @default.
- W2044188057 title "New Medical/Biologic Paradigms in the Treatment of Bone Tumors" @default.
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